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公开(公告)号：US20160250230A1
公开(公告)日：2016-09-01
申请号：US15154083
申请日：2016-05-13
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/07 , A61K47/38
CPC分类号： A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
摘要翻译： 用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。 将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工， 热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。
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公开(公告)号：US20210128536A1
公开(公告)日：2021-05-06
申请号：US17065664
申请日：2020-10-08
IPC分类号： A61K31/444 , A61K47/38 , A61K47/32 , A61K9/16 , A61K9/00 , A61K31/496 , A61K31/136 , A61K31/704 , A61K31/475 , A61K31/167 , A61K31/5415
摘要： The present disclosure relates to pharmaceutical formulations including a weakly basic drug and an ionic polymer in an amorphous solid dispersion, as well as methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations.
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公开(公告)号：US20200261473A1
公开(公告)日：2020-08-20
申请号：US16866676
申请日：2020-05-05
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K47/38 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/10 , A61J3/07 , A61J3/00 , A61K9/20 , A61K9/16 , A61K9/14
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20180360850A1
公开(公告)日：2018-12-20
申请号：US16012025
申请日：2018-06-19
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/16 , A61K9/20 , A61K9/14 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/00 , A61K47/38 , A61J3/07
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20230172949A1
公开(公告)日：2023-06-08
申请号：US17814567
申请日：2022-07-25
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/14 , A61K9/16 , A61K9/20 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
CPC分类号： A61K31/573 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61J3/00 , A61J3/07 , A61J3/10 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20170119669A1
公开(公告)日：2017-05-04
申请号：US15341217
申请日：2016-11-02
IPC分类号： A61K9/14 , A61K31/55 , A61K31/58 , A61K31/496 , A61K38/13
CPC分类号： A61K9/146 , A61K9/1635 , A61K9/1641 , A61K9/5138 , A61K31/496 , A61K31/55 , A61K31/58 , A61K38/13
摘要： A hot-melt extruded composition having finely divided drug-containing particles dispersed within a polymeric and/or lipophyllic carrier matrix is provided. The carrier softens or melts during hot-melt extrusion but it does not dissolve the drug-containing particles during extrusion. As a result, a majority or at least 90% wt. of the drug-containing particles in the extrudate are deaggregated during extrusion into essentially primary crystalline and/or amorphous particles. PEO is a suitable carrier material for drugs insoluble in the solid state in this carrier. Various functional excipients can be included in the carrier system to stabilize the particle size and physical state of the drug substance in either a crystalline and/or amorphous state. The carrier system is comprised of at least one thermal binder, and may also contain various functional excipients, such as: super-disintegrants, antioxidants, surfactants, wetting agents, stabilizing agents, retardants, or similar functional excipients. A hydrophilic polymer, such as hydroxypropyl methylcellulose (HPMC E15), polyvinyl alcohol (PVA), or poloxamer, and/or a surfactant, such as sodium lauryl sulfate (SLS), can be included in the composition. A process for preparing the extrudate is conducted at a temperature approximating or above the softening or melting temperature of the matrix and below the point of solubilization of drug-containing particles in the carrier system, and below the recrystallization point in the case of amorphous fine drug particles.
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公开(公告)号：US20170027911A1
公开(公告)日：2017-02-02
申请号：US15185888
申请日：2016-06-17
发明人： Dave A. MILLER , Justin M. KEEN , Sandra U. KUCERA
IPC分类号： A61K31/4196
CPC分类号： A61K31/4196 , A61K9/146 , A61K9/2054 , A61P39/04
摘要： The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.
摘要翻译： 本公开内容提供了含有地拉罗司（DFX）的改进的药物组合物及其制备方法。 特别地，使用热动力学复合制备组合物并提供改进的性能以及更有效的制造方法。
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公开(公告)号：US20170296514A1
公开(公告)日：2017-10-19
申请号：US15636174
申请日：2017-06-28
发明人： Dave A. MILLER , Justin M. KEEN , Sandra U. KUCERA
IPC分类号： A61K31/4196
CPC分类号： A61K31/4196 , A61K9/146 , A61K9/2054 , A61P39/04
摘要： The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.
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公开(公告)号：US20200009060A1
公开(公告)日：2020-01-09
申请号：US16098145
申请日：2017-05-08
IPC分类号： A61K9/20 , A61K31/437 , A61K31/496 , A61K31/4196
摘要： The disclosure provides for improved pharmaceutical compositions containing an active pharmaceutical ingredient and a non-polymeric lubricant and methods of manufacturing the same. In particular, the compositions are prepared using thermal processing or solvent sprying and provide improved properties as well as more efficient methods of manufacture.
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公开(公告)号：US20190167643A1
公开(公告)日：2019-06-06
申请号：US16268785
申请日：2019-02-06
发明人： Dave A. MILLER , Justin M. KEEN , Sandra U. KUCERA
IPC分类号： A61K31/4196 , A61P39/04 , A61K9/14 , A61K9/20
摘要： The disclosure provides for improved pharmaceutical compositions containing deferasirox (DFX) and methods of manufacturing the same. In particular, the compositions are prepared using thermokinetic compounding and provide improved properties as well as more efficient methods of manufacture.
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