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公开(公告)号：US20210260150A1
公开(公告)日：2021-08-26
申请号：US17274666
申请日：2019-09-10
发明人： Robert O. WILLIAMS, III , Alan B. WATTS , Yajie ZHANG , Sawittree SAHAKIJPIJARN , Dale CHRISTENSEN , John J. KOLENG
摘要： Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.
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公开(公告)号：US20240269225A1
公开(公告)日：2024-08-15
申请号：US18434731
申请日：2024-02-06
发明人： Robert O. WILLIAMS, III , Alan B. WATTS , Yajie ZHANG , Sawittree SAHAKIJPIJARN , Dale CHRISTENSEN , John J. KOLENG
CPC分类号： A61K38/08 , A61K9/0075 , A61K9/14 , A61K38/10 , A61K45/06 , A61P11/00 , C07K7/06 , C07K7/08 , C07K2319/10
摘要： Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.
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公开(公告)号：US20190269661A1
公开(公告)日：2019-09-05
申请号：US16294885
申请日：2019-03-06
发明人： Robert O. WILLIAMS, III , Keith P. JOHNSTON , Prapasri SINSWAT , Jason T. MCCONVILLE , Robert TALBERT , Jay I. PETERS , Alan B. WATTS , True L. ROGERS
摘要： The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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公开(公告)号：US20170165238A1
公开(公告)日：2017-06-15
申请号：US15385369
申请日：2016-12-20
发明人： Robert O. WILLIAMS, III , Keith P. JOHNSTON , Prapasri SINSWAT , Jason T. MCCONVILLE , Robert TALBERT , Jay I. PETERS , Alan B. WATTS , True L. ROGERS
IPC分类号： A61K31/436 , A61K9/19 , A61K9/51 , A61K38/13 , A61K9/00
CPC分类号： A61K31/436 , A61K9/0075 , A61K9/0078 , A61K9/1623 , A61K9/1694 , A61K9/19 , A61K9/5161 , A61K9/5192 , A61K38/13
摘要： The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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5.发明申请公开(公告)号：US20220354778A1
公开(公告)日：2022-11-10
申请号：US17746915
申请日：2022-05-17
IPC分类号： A61K9/00
摘要： The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
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6.发明申请公开(公告)号：US20210338671A1
公开(公告)日：2021-11-04
申请号：US17262313
申请日：2019-07-24
IPC分类号： A61K31/506 , A61K9/16 , A61K9/19 , A61K9/00
摘要： Pharmaceutical compositions which contain at less than 10% of an excipient and are presented as nanoaggregates are described herein. These pharmaceutical compositions have been shown to exhibit improved properties such as improved aerosolizability and aerodynamic performance. Also provided herein are methods of preparing the pharmaceutical compositions disclosed herein and use thereof.
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7.发明申请公开(公告)号：US20200069572A1
公开(公告)日：2020-03-05
申请号：US16555165
申请日：2019-08-29
IPC分类号： A61K9/00
摘要： The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
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公开(公告)号：US20230040283A1
公开(公告)日：2023-02-09
申请号：US17836067
申请日：2022-06-09
发明人： Robert O. WILLIAMS, III , Keith P. JOHNSTON , Prapasri SINSWAT , Jason T. MCCONVILLE , Robert TALBERT , Jay I. PETERS , Alan B. WATTS , True L. ROGERS
摘要： The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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9.发明申请公开(公告)号：US20210007971A1
公开(公告)日：2021-01-14
申请号：US16839957
申请日：2020-04-03
IPC分类号： A61K9/00
摘要： The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
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10.发明申请公开(公告)号：US20190117557A1
公开(公告)日：2019-04-25
申请号：US16115888
申请日：2018-08-29
IPC分类号： A61K9/00
摘要： The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrofluoroalkane propellant. A portion of the one or more flocculated particles is templated by the formation of hydrofluoroalkane droplets upon atomization and the templated floc compacts upon the evaporation of the hydrofluoroalkane propellant to form a porous particle for deep lung delivery.
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