公开(公告)号：US11840540B2

公开(公告)日：2023-12-12

申请号：US17382083

申请日：2021-07-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Amarnath Natarajan ,  Sandeep Rana

IPC: C07D487/10 ,  C07D491/107 ,  A61P35/00 ,  C07D519/00

CPC classification number: C07D491/107 ,  A61P35/00 ,  C07D487/10 ,  C07D519/00

Abstract: Provided herein are compounds and methods for modulating the NFκB pathway. More particularly, provided are inhibitors of the NFκB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.

公开(公告)号：US20220009941A1

公开(公告)日：2022-01-13

申请号：US17382083

申请日：2021-07-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Amarnath Natarajan ,  Sandeep Rana

IPC: C07D491/107 ,  A61P35/00 ,  C07D487/10 ,  C07D519/00

Abstract: Provided herein are compounds and methods for modulating the NFκB pathway. More particularly, provided are inhibitors of the NFκB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.

公开(公告)号：US11104684B2

公开(公告)日：2021-08-31

申请号：US16471070

申请日：2017-12-21

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Amarnath Natarajan ,  Sandeep Rana

IPC: C07D487/10 ,  C07D491/107 ,  A61P35/00 ,  C07D519/00

Abstract: Provided herein are compounds and methods for modulating the NFκB pathway. More particularly, provided are inhibitors of the NFκB pathway and the uses of such inhibitors in regulating diseases and disorders, e.g., to treat cancer, autoimmune diseases, inflammatory diseases, diabetes, cardiovascular diseases, or neurological diseases.