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公开(公告)号：US12018048B2
公开(公告)日：2024-06-25
申请号：US17643251
申请日：2021-12-08
IPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , A61P33/10 , A61P43/00 , C07D273/00 , C07D413/14
CPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , C07D273/00 , C07D413/14
摘要： Cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds are provided that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. Also provided are improved methods for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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公开(公告)号：US11497732B2
公开(公告)日：2022-11-15
申请号：US16534912
申请日：2019-08-07
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/422 , A61K47/14 , C07D491/107 , C07D261/04 , C07D471/04 , A01N43/80 , A61K9/00 , A61K47/10 , A61K31/415 , A61K31/42 , C07D413/04 , A61K9/10 , A61K9/08 , A61K9/107
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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公开(公告)号：US20220098241A1
公开(公告)日：2022-03-31
申请号：US17643251
申请日：2021-12-08
IPC分类号： C07K11/02 , C07D413/14 , A01N43/72 , C07D273/00 , A61K38/15 , A61K45/06
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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公开(公告)号：US11230571B2
公开(公告)日：2022-01-25
申请号：US16392412
申请日：2019-04-23
IPC分类号： C07K11/02 , A61K38/15 , A61K45/06 , A61P33/00 , A61P33/10 , A61P43/00 , C07D413/14 , A01N43/72 , C07D273/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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5.发明申请公开(公告)号：US20200038370A1
公开(公告)日：2020-02-06
申请号：US16534912
申请日：2019-08-07
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/415 , A61K31/42 , A61K31/422 , C07D413/04 , A61K47/14 , C07D491/107 , C07D261/04 , C07D471/04 , A01N43/80 , A61K9/00 , A61K47/10
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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公开(公告)号：US20190248840A1
公开(公告)日：2019-08-15
申请号：US16392412
申请日：2019-04-23
IPC分类号： C07K11/02 , A61K45/06 , A61K38/15 , C07D413/14 , A01N43/72 , C07D273/00
CPC分类号： C07K11/02 , A01N43/72 , A61K38/15 , A61K45/06 , C07D273/00 , C07D413/14
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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公开(公告)号：US10344056B2
公开(公告)日：2019-07-09
申请号：US15378219
申请日：2016-12-14
IPC分类号： A61P33/00 , C07K11/02 , A61K38/15 , A61K45/06 , C07D413/14 , A01N43/72 , C07D273/00
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used for combating parasites in or on animals including mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in animals, including birds and mammals.
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公开(公告)号：US11382949B2
公开(公告)日：2022-07-12
申请号：US16461741
申请日：2017-11-15
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US20190307838A1
公开(公告)日：2019-10-10
申请号：US16461741
申请日：2017-11-15
摘要： The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the naturally occurring cyclic depsipeptide PF1022A. The invention also provides compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.
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公开(公告)号：US12083100B1
公开(公告)日：2024-09-10
申请号：US17938063
申请日：2022-10-05
发明人： Loic Patrick Le Hir de Fallois , Charles Q. Meng , Susan Mancini Cady , Peter Cheifetz , Izabela Galeska
IPC分类号： A61K31/422 , A01N43/80 , A61K9/00 , A61K31/415 , A61K31/42 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A61K9/08 , A61K9/10 , A61K9/107
CPC分类号： A61K31/415 , A01N43/80 , A61K9/0019 , A61K31/42 , A61K31/422 , A61K47/10 , A61K47/14 , C07D261/04 , C07D413/04 , C07D471/04 , C07D491/107 , A61K9/0095 , A61K9/08 , A61K9/10 , A61K9/107
摘要： This invention relates to long-acting injectable compositions for combating parasites in animals, comprising at least one isoxazoline active agent, a liquid PEG and/or a neutral oil, optionally a co-solvent, and optionally a pharmaceutically acceptable additive or excipient. This invention also provides new isoxazoline active agents with long-lasting efficacy against ectoparasites. The invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the novel isoxazoline compounds and long-acting injectable compositions of the invention to the animal in need thereof.
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