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    Sulfonamides characterized by antidiabetic activity
    1.
    发明授权
    Sulfonamides characterized by antidiabetic activity 失效
    由抗生素活性表征的磺酰胺

    公开(公告)号：US3565897A

    公开(公告)日：1971-02-23

    申请号：US3565897D

    申请日：1968-10-04

    申请人： BOEHRINGER MANNHEIM GMBH

    发明人： HEERDT RUTH ,  HUBNER MANFRED ,  SCHMIDT FELIX HELMUT ,  STACH KURT ,  MUTH KARL

    IPC分类号： C07D239/69 ,  C07D51/42

    CPC分类号： C07D239/69 ,  Y10S514/866

    摘要： NOVEL HYDRINDENE-SULFONYLAMIDO-PYRIMIDEINES AND THE ALKALI SALTS THEREOF HAVING BLOOD SUGAR REDUCING PROPERTIES HAVING THE FORMULA:

    2-(((A-CO-N(-R1)-)INDANYL)-SO2-NH-),4-R1,5-R2-PYRIMIDINE

    WHEREIN A REPRESENTS SUBSTITUTED OR UNSUBSTITUTED ALKYL, ALKENYL, ARYL, ARALKYL, ARYLOXYALKYL, ARYLMERCAPTOALKYL, CYCLOALKYL, CYCLOALKENYL, THIENYL, FURYL, ALKOXY, ALKENYLOXY, ARALKOXY, CYCLOALKOXY, CYCLOALKYALKOXY, CYCLOALKENYLALKOXY, OR THE GROUP

    -N(-V)-W

    WHEREIN V AND W ARE EACH HYDROGEN, SUBSTITUTED OR UNSUBSTITUTED ALKYL, CYCLOALKYL, ARYL OR ARALKYL AND TAKEN TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE ATTACHED A SUBSTITUTED OR UNSBUSTITITED HETEROCYCLIC RING, R1 IS HYDROGEN, LOWER ALKYL OR SUBSTITUTED OR UNSUBSTITUTED ARALKYL, R2 IS ALKYL, CYCLOALKYL, CYCLOALKYL-ALKYL, ARYL, ARALKYL, ALKOXY, CYCLOALKOXY, ALKOXYALKYL, ALKOXYALKOXY OR ALKYLMERCAPTO WHICH CAN BE SUBSTITUTED BY HALOGEN, HYDROXY, OR ALKYL AND R3 IS HYDROGEN OR LOWER ALKYL, WHEREIN R2 AND R3 CAN BE JOINED TOGETHER TO FORM A RING COMPOSED OF 3 TO 5 METHYLENE GROUPS.