公开(公告)号：US3751408A

公开(公告)日：1973-08-07

申请号：US3751408D

申请日：1971-05-21

申请人： BOEHRINGER MANNHEIM GMBH

发明人： BERGMEYER H ,  STORK H ,  WEIMANN G ,  MICHAEL G ,  NELBOECK HOCHSTETTER M

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7056 ,  A61P3/06 ,  C07H19/052 ,  C07D51/52

CPC分类号： C07H19/052

摘要： CERTAIN NOVEL IMIDAZOLE-RIBOSYL CYCLOPHOSPHATE COMPOUNDS OF THE GENERAL FORMULA:

1-(3-HO,4,5-(-O-P(=O)(-OH)-O-CH2-)TETRAHYDROFUR-2-YL),

WHEREIN R IS A HYDROGEN ATOM OR A (CH2)N-A RADICAL, IN WHICH N IS 2 OR 3 A IS A SULFO OR COR'' GROUP AND R'' IS HYDROXYL, ALKOXY CONTAINING FROM 1 TO 6 CARBON ATOMS OR PROPIONAMIDO; AND THE SALTS THERREOF ARE OUTSTANDINGLY EFFECTIVE ANTI-HYPERLIPEMIC AGENTS AND, PARTICULARLY, AS ANTI-CHOLESTEROL AGENTS.

4-(R-NH-CO-),5-NH2-IMIDAZOLE