公开(公告)号：US20150105764A1

公开(公告)日：2015-04-16

申请号：US14572042

申请日：2014-12-16

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： RAED N. RIZQ ,  ROGER N. HASTINGS ,  DAVID J. SOGARD

IPC: A61B18/02

CPC classification number: A61B18/02 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0262

Abstract: A cryotherapy balloon catheter includes a compliant cryotherapy balloon comprising a distal balloon section dimensioned for placement within a renal artery and a proximal balloon section dimensioned to abut against an ostium of the renal artery and extend into at least a portion of the abdominal aorta. The compliant balloon has a diameter that varies non-uniformly along a length of the compliant balloon, such that a diameter at the proximal balloon section is larger than a diameter of the distal balloon section. The cryotherapy balloon catheter may be configured to deliver cryogenic therapy to at least the ostium of the renal artery sufficient to irreversibly terminate renal sympathetic nerve activity, such as by causing neurotmesis of renal nerve fibers and ganglia at the ostium of the renal artery.

Abstract translation: 冷冻治疗气囊导管包括顺应性冷冻治疗气囊，其包括尺寸适于放置在肾动脉内的远端球囊部分和近端球囊部分，其近似球囊部分的尺寸设置成抵靠肾动脉的口并且延伸到腹主动脉的至少一部分。 顺应性球囊具有沿着柔顺气囊的长度不均匀地变化的直径，使得近端球囊部分处的直径大于远端球囊部分的直径。 冷冻治疗气球导管可以被配置为将低温治疗递送至至少肾动脉的口，足以不可逆地终止肾交感神经活动，例如通过在肾动脉的口处引起肾神经纤维和神经节的神经痛。