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公开(公告)号：US20180036413A1
公开(公告)日：2018-02-08
申请号：US15660250
申请日：2017-07-26
申请人： BPSI Holdings, LLC
发明人： Jeffrey R. Gimbel , Daniel To , Jason Teckoe
CPC分类号： A61K47/36 , A61K9/0053 , A61K9/10 , A61K9/282 , A61K9/284 , A61K9/2853 , A61K9/286 , A61K9/2866 , A61K47/38 , A61K47/44
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a water-soluble polymer and guar gum. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the water-soluble polymer is a cellulosic or vinyl polymer. Aqueous suspensions containing the inventive film coating compositions and the coated substrates themselves are also disclosed. The resulting coated substrates have relatively low coefficients of static and dynamic friction on wet surfaces rendering them easier to swallow than prior art compositions.
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2.发明授权Enhanced moisture barrier immediate release film coating systems and substrates coated therewith 有权增强的防潮快速脱膜膜涂层系统和涂覆的基材公开(公告)号：US09028862B2
公开(公告)日：2015-05-12
申请号：US14156060
申请日：2014-01-15
申请人： BPSI Holdings, LLC.
发明人： Thomas P. Farrell , Jason Teckoe
CPC分类号： A61K9/2866 , A61K9/284 , A61K9/2846 , A61K47/02
摘要： The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。 膜涂层系统可以直接施加到基底上，或者在基底涂覆有底涂层之后。 在优选的方面，防潮膜涂层被制备为含有聚乙烯醇，具有pH依赖性溶解度的聚合物，增塑剂，助流剂和任选的防粘剂，碱化剂和颜料的干粉混合物。 还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物，将涂料施加到基材和涂布的基材上的方法。
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公开(公告)号：US20190314286A1
公开(公告)日：2019-10-17
申请号：US16369251
申请日：2019-03-29
申请人： BPSI Holdings LLC
发明人： Raxitkumar Y. Mehta , George Reyes , Jason Teckoe , Daniel To
摘要： The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
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4.发明申请IMMEDIATE RELEASE FILM COATINGS CONTAINING MEDIUM CHAIN GLYCERIDES AND SUBSTRATES COATED THEREWITH 审中-公开立即发布包含中链甘油的薄膜和包覆在其上的基材公开(公告)号：US20170035697A1
公开(公告)日：2017-02-09
申请号：US15332319
申请日：2016-10-24
申请人： BPSI Holdings, LLC
发明人： Jason Teckoe , Bradley J. Prusak , Jeffrey R. Gimbel , Daniel To
IPC分类号： A61K9/28
CPC分类号： A61K9/282 , A61K9/2813 , A61K9/284 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和其它含有中链甘油酯作为防粘剂的其它可口服摄取底物的速释薄膜包衣组合物。 膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是聚乙烯醇，中链甘油酯是甘油的辛酸（8碳链）和癸酸（10个碳链）单酯和二酯的混合物。 还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施涂到基材和涂布的基材本身上的方法。
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公开(公告)号：US10232045B2
公开(公告)日：2019-03-19
申请号：US15660250
申请日：2017-07-26
申请人： BPSI Holdings, LLC
发明人： Jeffrey R. Gimbel , Daniel To , Jason Teckoe
摘要： The present invention is directed to film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain a water-soluble polymer and guar gum. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the water-soluble polymer is a cellulosic or vinyl polymer. Aqueous suspensions containing the inventive film coating compositions and the coated substrates themselves are also disclosed. The resulting coated substrates have relatively low coefficients of static and dynamic friction on wet surfaces rendering them easier to swallow than prior art compositions.
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6.发明授权公开(公告)号：US09789067B2
公开(公告)日：2017-10-17
申请号：US15332319
申请日：2016-10-24
申请人： BPSI Holdings, LLC
发明人： Jason Teckoe , Bradley J. Prusak , Jeffrey R. Gimbel , Daniel To
CPC分类号： A61K9/282 , A61K9/2813 , A61K9/284 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
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公开(公告)号：US10758489B2
公开(公告)日：2020-09-01
申请号：US16369251
申请日：2019-03-29
申请人： BPSI Holdings LLC
发明人： Raxitkumar Y. Mehta , George Reyes , Jason Teckoe , Daniel To
IPC分类号： A61K9/28 , A61K9/20 , C08K5/092 , C09D101/28 , C09D7/63
摘要： The present invention includes acidifying film coating compositions containing a polymer and an acidic component for use on orally-ingestible substrates such as tablets and the like. The acidifying coating compositions can be applied as an aqueous dispersion to an enteric-coated substrate to increase the disintegration resistance to aqueous media of up to pH 5.0. In preferred aspects, the acidic component is citric acid, lactic acid, stearic acid or mixtures thereof. Methods of preparing the dry film coatings, methods of preparing corresponding aqueous dispersions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
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8.发明授权Immediate release film coatings containing medium chain glycerides and substrates coated therewith 有权含有中链甘油酯和其上涂覆的基材的立即脱模薄膜包衣公开(公告)号：US09504654B2
公开(公告)日：2016-11-29
申请号：US14597025
申请日：2015-01-14
申请人： BPSI Holdings, LLC
发明人： Jason Teckoe , Bradley J. Prusak , Jeffrey R. Gimbel , Daniel To
CPC分类号： A61K9/282 , A61K9/2813 , A61K9/284 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和其它含有中链甘油酯作为防粘剂的其它可口服摄取底物的速释薄膜包衣组合物。 膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是聚乙烯醇，中链甘油酯是甘油的辛酸（8碳链）和癸酸（10个碳链）单酯和二酯的混合物。 还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施涂到基材和涂布的基材本身上的方法。
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9.发明申请IMMEDIATE RELEASE FILM COATINGS CONTAINING MEDIUM CHAIN GLYCERIDES AND SUBSTRATES COATED THEREWITH 有权立即发布包含中链甘油的薄膜和包覆在其上的基材公开(公告)号：US20150202160A1
公开(公告)日：2015-07-23
申请号：US14597025
申请日：2015-01-14
申请人： BPSI Holdings, LLC
发明人： Jason Teckoe , Bradley J. Prusak , Jeffrey R. Gimbel , Daniel To
IPC分类号： A61K9/28
CPC分类号： A61K9/282 , A61K9/2813 , A61K9/284 , A61K9/2866 , A61K9/2893
摘要： The present invention is directed to immediate release film coating compositions for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which contain medium chain glycerides as detackifiers. The film coating compositions can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the polymer is polyvinyl alcohol and the medium chain glycerides are mixtures of caprylic (8 carbon chain) and capric (10 carbon chain) mono- and diesters of glycerin. Aqueous suspensions comprising the inventive film coating compositions, methods of applying the coatings to substrates and the coated substrates themselves are also disclosed.
摘要翻译： 本发明涉及用于口服剂型例如压缩片剂和其它含有中链甘油酯作为防粘剂的其它可口服摄取底物的速释薄膜包衣组合物。 膜涂层组合物可以直接施加到基底上，或者在基底已经被底涂层涂覆之后。 在优选的方面，聚合物是聚乙烯醇，中链甘油酯是甘油的辛酸（8碳链）和癸酸（10个碳链）单酯和二酯的混合物。 还公开了包含本发明的薄膜涂料组合物的水性悬浮液，将涂料施涂到基材和涂布的基材本身上的方法。
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