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    Fluorescent solid lipid nanoparticles composition and preparation thereof
    1.
    发明授权
    Fluorescent solid lipid nanoparticles composition and preparation thereof 有权

    公开(公告)号：US10780184B2

    公开(公告)日：2020-09-22

    申请号：US16263769

    申请日：2019-01-31

    申请人： BRACCO IMAGING S.P.A.

    发明人： Simona Ghiani ,  Alessandro Maiocchi ,  Lara Caminiti ,  Luigi Miragoli

    IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  A61K9/10 ,  A61K9/51

    摘要： The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

    Fluorescent solid lipid nanoparticles composition and preparation thereof
    3.
    发明授权
    Fluorescent solid lipid nanoparticles composition and preparation thereof 有权

    公开(公告)号：US10251960B2

    公开(公告)日：2019-04-09

    申请号：US14894505

    申请日：2014-05-28

    申请人： BRACCO IMAGING S.P.A.

    发明人： Simona Ghiani ,  Alessandro Maiocchi ,  Lara Caminiti ,  Luigi Miragoli

    IPC分类号： A61B5/00 ,  A61B8/00 ,  A61B10/00 ,  A61K49/00 ,  A61K9/51 ,  A61K9/10

    摘要： The present invention discloses a solid lipid nanoparticle (SLN) comprising: a) a solid lipid core comprising at least a glyceride and/or at least a fatty acid; b) a mixture of amphiphilic components forming a shell around said core a); c) an alkaline-earth complex with a compound of formula I and/or II: d) at least a fluorescent dye selected from: a cyanine fluorescent dye and/or a polyetherocyclic compound selected from: coumarin, pyrano, quinoline, pyranoquinoline, indole and pyranoindole derivates in acid form or a pharmaceutically acceptable salt thereof. These nanoparticles allow a prolonged blood circulation half-life, show enhanced photostability and improved fluorescence signal. The dye is preserved from degradation and improves the fluorescent quantum yield.

    Paramagnetic Solid Lipid Nanoparticles (pSLNs) Containing Metal Amphiphilic Complexes For MRI
    6.
    发明申请
    Paramagnetic Solid Lipid Nanoparticles (pSLNs) Containing Metal Amphiphilic Complexes For MRI 审中-公开
    含有金属两亲性配合物的磁共振固体脂质纳米粒子（pSLN）用于MRI

    公开(公告)号：US20150258221A1

    公开(公告)日：2015-09-17

    申请号：US14426036

    申请日：2013-09-06

    申请人： BRACCO IMAGING S.P.A.

    发明人： Chiara Brioschi ,  Claudia Cabella ,  Simona Ghiani ,  Alessandro Maiocchi ,  Luigi Miragoli ,  Massimo Visigalli

    IPC分类号： A61K49/10 ,  A61K49/08 ,  A61K49/18

    CPC分类号： A61K49/106 ,  A61K49/085 ,  A61K49/101 ,  A61K49/1881

    摘要： The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.

    摘要翻译： 本发明涉及包含选自以下的两亲顺磁金属螯合部分的顺磁性固体脂质纳米粒子（pSLN）：式I的二氮杂衍生物和式（II）的四氮杂环十二烷衍生物：所述螯合部分与选自以下的顺磁性金属离子络合： 由Gd（III），Mn（II），Cr（III），Cu（II），Fe（Ⅲ），Pr（Ⅲ），Nd（Ⅲ），Sm（Ⅲ），Tb（Ⅲ） Yb（III），Dy（III），Ho（III）和Er（III），或其盐。 本发明还涉及制备包含顺磁性金属（pSLN）的两亲性复合物的所述固体脂质纳米粒子的方法以及在诊断领域中使用pSLN作为MRI造影剂的方法。