公开(公告)号：US11408889B2

公开(公告)日：2022-08-09

申请号：US16870006

申请日：2020-05-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xi-Tao Wang ,  Olufemi A. Adelakun ,  Anne C. Lewin ,  Alan J. Korman ,  Mark J. Selby ,  Changyu Wang ,  Haichun Huang ,  Karla A. Henning ,  Nils Lonberg ,  Mohan Srinivasan ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Susan Chien-Szu Wong ,  Huiming Li

IPC: G01N33/566 ,  G01N33/574 ,  C07K16/28

Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

公开(公告)号：US10690674B2

公开(公告)日：2020-06-23

申请号：US15578874

申请日：2016-06-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Xi-Tao Wang ,  Olufemi A. Adelakun ,  Anne C. Lewin ,  Alan J. Korman ,  Mark J. Selby ,  Changyu Wang ,  Haichun Huang ,  Karla A. Henning ,  Nils Lonberg ,  Mohan Srinivasan ,  Michelle Minhua Han ,  Guodong Chen ,  Richard Y. Huang ,  Indrani Chakraborty ,  Susan Chien-Szu Wong ,  Huiming Li

IPC: G01N33/566 ,  G01N33/574 ,  C07K16/28

Abstract: Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.