公开(公告)号：US11155618B2

公开(公告)日：2021-10-26

申请号：US16371964

申请日：2019-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Achal Pashine ,  Michael L. Gosselin ,  Aaron P. Yamniuk ,  Derek A. Holmes ,  Guodong Chen ,  Priyanka Apurva Madia ,  Richard Yu-Cheng Huang ,  Stephen Michael Carl

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28 ,  A61K47/68 ,  C12N15/85 ,  A61P29/00

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

公开(公告)号：US11952420B2

公开(公告)日：2024-04-09

申请号：US17472051

申请日：2021-09-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Achal Pashine ,  Michael L Gosselin ,  Aaron P. Yamniuk ,  Derek A. Holmes ,  Guodong Chen ,  Priyanka Apurva Madia ,  Richard Yu-Cheng Huang ,  Stephen Michael Carl

IPC: C07K16/28 ,  A61K47/68 ,  A61P29/00 ,  C12N15/13 ,  C12N15/63 ,  C12N15/85

CPC classification number: C07K16/2803 ,  A61K47/6803 ,  A61P29/00 ,  C12N15/85 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

公开(公告)号：US11919954B2

公开(公告)日：2024-03-05

申请号：US17472302

申请日：2021-09-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Achal Pashine ,  Michael L. Gosselin ,  Aaron P. Yamniuk ,  Derek A. Holmes ,  Guodong Chen ,  Priyanka Apurva Madia ,  Richard Yu-Cheng Huang ,  Stephen Michael Carl

IPC: A61K39/395 ,  A61K47/68 ,  A61P29/00 ,  C07K16/18 ,  C07K16/28 ,  C12N15/85

CPC classification number: C07K16/2803 ,  A61K47/6803 ,  A61P29/00 ,  C12N15/85 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/90 ,  C07K2317/92

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.

公开(公告)号：US20190300608A1

公开(公告)日：2019-10-03

申请号：US16371964

申请日：2019-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Achal Pashine ,  Michael L. Gosselin ,  Aaron P. Yamniuk ,  Derek A. Holmes ,  Guodong Chen ,  Priyanka Apurva Madia

IPC: C07K16/28 ,  A61K47/68 ,  C12N15/85

Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.