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公开(公告)号：US11203630B2
公开(公告)日：2021-12-21
申请号：US16549462
申请日：2019-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N5/20 , C12N1/20 , C12N15/00 , C07K14/78 , A61K47/64 , A61K38/00
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US11434275B2
公开(公告)日：2022-09-06
申请号：US16748085
申请日：2020-01-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley Richard Krystek, Jr. , Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Juhi Juneja
IPC: C07K14/78 , C07K14/765 , C12N15/85
Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin. Also provided are fusion molecules comprising a serum albumin binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US20220204589A1
公开(公告)日：2022-06-30
申请号：US17527238
申请日：2021-11-16
Applicant: Bristol-Myers Squibb Company
Inventor： Tracy S. MITCHELL , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US10934572B2
公开(公告)日：2021-03-02
申请号：US16244921
申请日：2019-01-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
IPC: C12P21/00 , C12N15/62 , A61K47/62 , A61K47/64 , C07K14/78 , C07K14/435 , C07K14/50 , C07K14/575 , A61K38/00
Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US11155618B2
公开(公告)日：2021-10-26
申请号：US16371964
申请日：2019-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Achal Pashine , Michael L. Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
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Patent Agency Ranking
公开(公告)号：US10766946B2
公开(公告)日：2020-09-08
申请号：US15760413
申请日：2016-09-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley Richard Krystek, Jr. , Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Juhi Juneja
IPC: C07K14/78 , C07K14/765 , C12N15/85
Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin. Also provided are fusion molecules comprising a serum albumin binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US10221438B2
公开(公告)日：2019-03-05
申请号：US15363724
申请日：2016-11-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukherjee , Simeon I. Taylor
IPC: A61K38/00 , A61K47/62 , A61K47/64 , C07K14/50 , C07K14/78 , C12N15/62 , C12P21/00 , C07K14/435 , C07K14/575
Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US09540424B2
公开(公告)日：2017-01-10
申请号：US14552823
申请日：2014-11-25
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael L. Gosselin , David Fabrizio , Joanna F. Swain , Tracy Mitchell , Ray Camphausen , Sharon T. Cload , Eric Furfine , Paul E. Morin , Ranjan Mukerjee , Simeon I. Taylor
IPC: A61K38/00 , C07K14/435 , A61K47/48 , C07K14/78 , C12N15/62 , C07K14/50 , C07K14/575
CPC classification number: C12P21/005 , A61K38/00 , A61K47/62 , A61K47/643 , C07K14/435 , C07K14/50 , C07K14/575 , C07K14/78 , C07K2319/70 , C12N15/62
Abstract: The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain (10Fn3) that binds to serum albumin. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
Abstract translation: 本发明涉及基于结合血清白蛋白的第十纤连蛋白III型结构域（10Fn3）的抗体样蛋白。 本发明还涉及包含与用于诊断和治疗应用的异源蛋白质连接的血清白蛋白结合10Fn3的融合分子。
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公开(公告)号：US11919954B2
公开(公告)日：2024-03-05
申请号：US17472302
申请日：2021-09-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Achal Pashine , Michael L. Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
CPC classification number: C07K16/2803 , A61K47/6803 , A61P29/00 , C12N15/85 , C07K2317/32 , C07K2317/565 , C07K2317/90 , C07K2317/92
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
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公开(公告)号：US10442851B2
公开(公告)日：2019-10-15
申请号：US15127166
申请日：2015-03-19
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan Davis , David Fabrizio
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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