-
公开(公告)号：US11952420B2
公开(公告)日：2024-04-09
申请号：US17472051
申请日：2021-09-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Achal Pashine , Michael L Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
CPC classification number: C07K16/2803 , A61K47/6803 , A61P29/00 , C12N15/85 , C07K2317/32 , C07K2317/565 , C07K2317/90 , C07K2317/92
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
-
公开(公告)号：US20240417478A1
公开(公告)日：2024-12-19
申请号：US18423762
申请日：2024-01-26
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
-
Patent Agency Ranking
公开(公告)号：US20220017627A1
公开(公告)日：2022-01-20
申请号：US17232979
申请日：2021-04-16
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
-
公开(公告)号：US11155618B2
公开(公告)日：2021-10-26
申请号：US16371964
申请日：2019-04-01
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Achal Pashine , Michael L. Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
-
公开(公告)号：US11919962B2
公开(公告)日：2024-03-05
申请号：US17232979
申请日：2021-04-16
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
CPC classification number: C07K16/2866 , A61P29/00 , C12N15/63 , A61K2039/505 , C07K2317/565
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
-
公开(公告)号：US11919954B2
公开(公告)日：2024-03-05
申请号：US17472302
申请日：2021-09-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Achal Pashine , Michael L. Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
CPC classification number: C07K16/2803 , A61K47/6803 , A61P29/00 , C12N15/85 , C07K2317/32 , C07K2317/565 , C07K2317/90 , C07K2317/92
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
-
公开(公告)号：US11008395B2
公开(公告)日：2021-05-18
申请号：US16748518
申请日：2020-01-21
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
-
-
-
-
-
-
Search Results
7
records
(took 0.012 seconds)
