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公开(公告)号：US20220017627A1
公开(公告)日：2022-01-20
申请号：US17232979
申请日：2021-04-16
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
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公开(公告)号：US12129297B2
公开(公告)日：2024-10-29
申请号：US16961545
申请日：2019-01-11
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min Schebye , Mark J. Selby , Michelle Minhua Han , Christine Bee , Andy X. Deng , Anan Chuntharapai , Brigitte Devaux , Huiming Li , Paul O. Sheppard , Alan J. Korman , Daniel F. Ardourel , Ekaterina Deyanova , Richard Yu-Cheng Huang , Guodong Chen , Michelle Kuhne , Hong-An Truong
CPC classification number: C07K16/2803 , A61P35/00 , G01N33/6854 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/74 , C07K2317/76 , C07K2317/92 , G01N2333/70503
Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.
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公开(公告)号：US10023634B2
公开(公告)日：2018-07-17
申请号：US15649380
申请日：2017-07-13
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min Schebye , Mark J. Selby , Michelle Minhua Han , Christine Bee , Andy X. Deng , Anan Chuntharapai , Brigitte Devaux , Huiming Li , Paul O. Sheppard , Alan J. Korman , Daniel F. Ardourel , Ekaterina Deyanova , Richard Huang , Guodong Chen , Michelle Kuhne , Hong-An Troung
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US12110337B2
公开(公告)日：2024-10-08
申请号：US17045143
申请日：2019-04-03
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Li-Sheng Lu , Mark J. Selby , Alan J. Korman , Shrikant Deshpande , Mohan Srinivasan , Jun Zhang , Haichun Huang , Guodong Chen , Richard Y. Huang , Ekaterina Deyanova
IPC: C07K16/28 , A61K39/395 , A61P35/00 , A61K39/00
CPC classification number: C07K16/2878 , A61K39/39541 , A61P35/00 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/74 , C07K2317/75 , C07K2317/92
Abstract: This disclosure provides isolated antibodies that bind specifically to CD27 with high affinity. The disclosure provides methods for treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an anti-CD27 antibody as monotherapy or in combination with a checkpoint inhibitor, such as an anti-PD-1, anti-PD-L1, or anti-CTLA-4 antibody.
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公开(公告)号：US11591392B2
公开(公告)日：2023-02-28
申请号：US16697653
申请日：2019-11-27
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min Schebye , Mark J. Selby , Michelle Minhua Han , Christine Bee , Andy X. Deng , Anan Chuntharapai , Brigitte Devaux , Huiming Li , Paul O. Sheppard , Alan J. Korman , Daniel F. Ardourel , Ekaterina Deyanova , Richard Huang , Guodong Chen , Michelle Kuhne , Hong-An Truong
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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Patent Agency Ranking
公开(公告)号：US10533052B2
公开(公告)日：2020-01-14
申请号：US16017489
申请日：2018-06-25
Applicant: Bristol-Myers Squibb Company
Inventor： Xiao Min Schebye , Mark J. Selby , Michelle Minhua Han , Christine Bee , Andy X. Deng , Anan Chuntharapai , Brigitte Devaux , Huiming Li , Paul O. Sheppard , Alan J. Korman , Daniel F. Ardourel , Ekaterina Deyanova , Richard Huang , Guodong Chen , Michelle Kuhne , Hong-An Truong
Abstract: Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.
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公开(公告)号：US20240228664A9
公开(公告)日：2024-07-11
申请号：US18357007
申请日：2023-07-21
Applicant: Bristol-Myers Squibb Company
Inventor： Lin Hui Su , Ekaterina Deyanova , Burce Ergel Gurbuzbalaban , Mariana Nacht , Samantha Elaine Pace , Yun Wang , Qing Xiao , Ramakrishna Chandran , Shailesh Dudhgaonkar , Michael Louis Doyle , Michael Gilman , Richard Huang , Akbar Nayeem , Alok Sharma , Qihong Zhao
CPC classification number: C07K16/40 , A01N1/0226 , A61K45/06 , A61K47/6871 , A61K49/0002 , A61P19/02 , A61P37/06
Abstract: The present application relates to particular anti-PAD4 (peptidyl arginine deiminase 4) antibodies, nucleic acids encoding the antibodies, vectors and host cells comprising the nucleic acids, and methods of making and using the antibodies.
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公开(公告)号：US11919962B2
公开(公告)日：2024-03-05
申请号：US17232979
申请日：2021-04-16
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
CPC classification number: C07K16/2866 , A61P29/00 , C12N15/63 , A61K2039/505 , C07K2317/565
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
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公开(公告)号：US11008395B2
公开(公告)日：2021-05-18
申请号：US16748518
申请日：2020-01-21
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
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公开(公告)号：US20240417478A1
公开(公告)日：2024-12-19
申请号：US18423762
申请日：2024-01-26
Applicant: Bristol Myers-Squibb Company
Inventor： Aaron Paul Yamniuk , Scott Ronald Brodeur , Ekaterina Deyanova , Richard Yu-Cheng Huang , Yun Wang , Alfred Robert Langish , Guodong Chen , Stephen Michael Carl , Hong Shen , Achal Mukundrao Pashine , Lin Hui Su
Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7Rα). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.
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