公开(公告)号：US11827695B2

公开(公告)日：2023-11-28

申请号：US17152051

申请日：2021-01-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael K. Ahlijanian ,  Jere Ernest Meredith, Jr. ,  Nino Devidze ,  John David Graef ,  Edward L. Halk

IPC: C07K16/18 ,  A61K39/395 ,  A61P25/16 ,  A61P25/28

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61P25/16 ,  A61P25/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/92

Abstract: Disclosed herein are anti-α-synuclein antibodies which preferentially bind to oligomeric α-synuclein over monomeric α-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.

公开(公告)号：US11142570B2

公开(公告)日：2021-10-12

申请号：US16486238

申请日：2018-02-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael K. Ahlijanian ,  Jere Ernest Meredith, Jr. ,  Nino Devidze ,  John David Graef ,  Edward L. Halk

IPC: C07K16/18 ,  A61K39/395

Abstract: Disclosed herein are anti-α-synuclein antibodies which preferentially bind to oligomeric α-synuclein over monomeric α-synuclein, therapeutic compositions comprising the antibodies, and methods of using the antibodies to treat synucleinopathies.