公开(公告)号：US10221232B2

公开(公告)日：2019-03-05

申请号：US15404749

申请日：2017-01-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  David Fabrizio ,  Martin C. Wright ,  Patrick Gage ,  John Mendlein

IPC: C07K14/78 ,  C07K14/47 ,  C07K14/71 ,  A61K38/39 ,  A61K39/395 ,  C07K19/00 ,  C12N15/10 ,  C40B30/04 ,  C40B40/08 ,  A61K38/18 ,  C07K14/00 ,  C07K14/765 ,  C07K14/79 ,  C07K16/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  C07K16/22 ,  C07K16/28 ,  A61K39/00 ,  C40B40/10

Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US11149077B2

公开(公告)日：2021-10-19

申请号：US16244851

申请日：2019-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  David Fabrizio ,  Martin C. Wright ,  Patrick Gage ,  John Mendlein

IPC: C07K14/78 ,  C07K14/71 ,  C07K16/28 ,  A61K38/17 ,  A61K38/39 ,  A61K39/395 ,  A61K47/10 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  C12N15/10 ,  C40B30/04 ,  C40B40/08 ,  A61K38/18 ,  C07K14/00 ,  C07K14/765 ,  C07K14/79 ,  C07K16/00 ,  C07K14/47 ,  A61K39/00 ,  C07K19/00 ,  C40B40/10

Abstract: The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins.