公开(公告)号：US20210053972A1

公开(公告)日：2021-02-25

申请号：US16963557

申请日：2019-01-23

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Juliang ZHU ,  Paul Michael SCOLA

IPC: C07D471/10 ,  A61K31/438 ,  C07K14/705

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20190185450A1

公开(公告)日：2019-06-20

申请号：US16315800

申请日：2017-07-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kap-Sun YEUNG ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  Zhaoxing Meng ,  Paul Michael Scola

IPC: C07D401/10 ,  C07D413/14 ,  C07D417/14 ,  C07D417/12 ,  C07D405/14 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/498

Abstract: The present disclosure generally relates to compounds of formula (I), wherein R2 is a phenyl or pyridinyl moiety, useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20240124417A1

公开(公告)日：2024-04-18

申请号：US17766483

申请日：2020-10-01

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Denis R. ST. LAURENT ,  Li-Qiang SUN ,  Zhiwei YIN ,  Katharine A. GRANT-YOUNG ,  Paul Michael SCOLA

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D401/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D401/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20210094932A1

公开(公告)日：2021-04-01

申请号：US16977374

申请日：2019-02-28

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Denis R. ST. LAURENT ,  David R. LANGLEY ,  Paul Michael SCOLA

IPC: C07D401/12 ,  C07D401/14 ,  C07D213/85

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20200181125A1

公开(公告)日：2020-06-11

申请号：US16499009

申请日：2018-03-26

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Denis R. ST. LAURENT ,  Jeffrey Lee ROMINE ,  Paul Michael SCOLA

IPC: C07D405/14 ,  C07D405/12 ,  C07D401/14 ,  C07D401/12

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various pp diseases, including cancer and infectious diseases. (I)

公开(公告)号：US20190352280A1

公开(公告)日：2019-11-21

申请号：US16471531

申请日：2017-12-19

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Katharine A. GRANT-YOUNG ,  Li-Qiang SUN ,  David R. LANGLEY ,  Denis R. ST. LAURENT ,  Paul M. SCOLA

IPC: C07D401/14 ,  C07D471/08 ,  C07D413/14

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.