公开(公告)号：US08765767B2

公开(公告)日：2014-07-01

申请号：US13826760

申请日：2013-03-14

申请人： Bristol-Myers Squibb Company

发明人： Ronald J. Mattson ,  Zhaoxing Meng

IPC分类号： C07D239/42 ,  C07D401/04 ,  A01N43/42 ,  A61K31/44 ,  C07D513/02 ,  C07D515/02 ,  C07D417/00 ,  C07D419/00

CPC分类号： C07D471/04

摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.

摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物调节mGluR2受体并且可用于治疗中枢神经系统的各种疾病。

公开(公告)号：US20130245042A1

公开(公告)日：2013-09-19

申请号：US13826760

申请日：2013-03-14

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ronald J. Mattson ,  Zhaoxing Meng

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system.

摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物调节mGluR2受体并且可用于治疗中枢神经系统的各种疾病。

公开(公告)号：US20180057455A1

公开(公告)日：2018-03-01

申请号：US15689115

申请日：2017-08-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： KAP-SUN YEUNG ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  David R. Langley ,  Piyasena Hewawasam ,  Tao Wang ,  Zhongxing Zhang ,  Zhaoxing Meng ,  Li-Qiang Sun ,  Eric Mull ,  Paul Michael Scola

IPC分类号： C07D207/12 ,  C07D211/66 ,  C07D207/16 ,  C07D403/12 ,  C07D401/12 ,  C07D207/14 ,  C07D211/22 ,  C07D213/38 ,  C07D401/14 ,  C07C237/06 ,  C07D295/088 ,  C07D205/04 ,  C07D213/85 ,  C07C217/18 ,  C07D213/73 ,  C07D405/12 ,  C07C255/24 ,  C07D413/14 ,  C07D405/14 ,  C07D213/79 ,  C07D231/12 ,  C07D239/26 ,  C07D277/28 ,  C07D211/90

CPC分类号： C07D207/12 ,  C07C217/18 ,  C07C217/28 ,  C07C217/58 ,  C07C229/14 ,  C07C235/08 ,  C07C237/04 ,  C07C237/06 ,  C07C255/24 ,  C07C255/25 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D211/46 ,  C07D211/58 ,  C07D211/60 ,  C07D211/66 ,  C07D211/90 ,  C07D213/38 ,  C07D213/42 ,  C07D213/55 ,  C07D213/73 ,  C07D213/79 ,  C07D213/85 ,  C07D231/12 ,  C07D239/26 ,  C07D277/28 ,  C07D295/088 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12

摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US10745382B2

公开(公告)日：2020-08-18

申请号：US15290167

申请日：2016-10-11

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Kap-Sun Yeung ,  Timothy P. Connolly ,  David B. Frennesson ,  Katharine A. Grant-Young ,  Piyasena Hewawasam ,  David R. Langley ,  Zhaoxing Meng ,  Eric Mull ,  Kyle E. Parcella ,  Mark George Saulnier ,  Li-Qiang Sun ,  Alan Xiangdong Wang ,  Ningning Xu ,  Juliang Zhu ,  Paul Michael Scola

IPC分类号： C07D401/14 ,  C07D213/71 ,  C07D455/02 ,  A61K31/135 ,  A61K31/138 ,  A61K31/166 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C215/20 ,  C07C235/46 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D265/30 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/08

摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US10590105B2

公开(公告)日：2020-03-17

申请号：US16315800

申请日：2017-07-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Kap-Sun Yeung ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  Zhaoxing Meng ,  Paul Michael Scola

IPC分类号： C07D401/10 ,  C07D413/14 ,  C07D417/12 ,  C07D405/12 ,  C07D401/14 ,  C07D413/12 ,  C07D401/12 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/498 ,  A61K45/06 ,  C07D405/14 ,  C07D417/14

摘要： The present disclosure generally relates to compounds of formula (I), wherein R2 is a phenyl or pyridinyl moiety, useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20190185450A1

公开(公告)日：2019-06-20

申请号：US16315800

申请日：2017-07-05

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Kap-Sun YEUNG ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  Zhaoxing Meng ,  Paul Michael Scola

IPC分类号： C07D401/10 ,  C07D413/14 ,  C07D417/14 ,  C07D417/12 ,  C07D405/14 ,  A61K45/06 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/498

摘要： The present disclosure generally relates to compounds of formula (I), wherein R2 is a phenyl or pyridinyl moiety, useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US10144706B2

公开(公告)日：2018-12-04

申请号：US15689115

申请日：2017-08-29

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Kap-Sun Yeung ,  Katharine A. Grant-Young ,  Juliang Zhu ,  Mark G. Saulnier ,  David B. Frennesson ,  David R. Langley ,  Piyasena Hewawasam ,  Tao Wang ,  Zhongxing Zhang ,  Zhaoxing Meng ,  Li-Qiang Sun ,  Eric Mull ,  Paul Michael Scola

IPC分类号： C07D207/12 ,  C07D217/18 ,  C07D237/06 ,  C07D205/04 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D211/66 ,  C07D211/90 ,  C07D213/38 ,  C07D213/73 ,  C07D213/79 ,  C07D213/85 ,  C07D231/12 ,  C07D239/26 ,  C07D277/28 ,  C07D295/088 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D401/04 ,  C07D405/06 ,  C07D417/12 ,  C07D211/46 ,  C07D211/58 ,  C07D211/60 ,  C07D213/42 ,  C07D213/55 ,  C07C237/04 ,  C07C235/08 ,  C07C229/14 ,  C07C217/58 ,  C07C217/28 ,  C07C217/18 ,  C07C237/06 ,  C07C255/24 ,  C07C255/25

摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US09682980B2

公开(公告)日：2017-06-20

申请号：US14406029

申请日：2013-06-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ronald J. Mattson ,  Zhaoxing Meng ,  Leatte R. Guernon

IPC分类号： C07D491/107 ,  C07D487/04

CPC分类号： C07D487/04 ,  C07D491/107

摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system. Formula (I):

公开(公告)号：US20170107202A1

公开(公告)日：2017-04-20

申请号：US15290167

申请日：2016-10-11

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： KAP-SUN YEUNG ,  Timothy P. Connolly ,  David B. Frennesson ,  Katharine A. Grant-Young ,  Piyasena Hewawasam ,  David R. Langley ,  Zhaoxing Meng ,  Eric Mull ,  Kyle E. Parcella ,  Mark George Saulnier ,  Li-Qiang Sun ,  Alan Xiangdong Wang ,  Ningning Xu ,  Juliang Zhu ,  Paul Michael Scola

IPC分类号： C07D401/14 ,  A61K31/5377 ,  C07D213/85 ,  A61K31/4439 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/44 ,  C07D471/04 ,  C07D405/14 ,  A61K31/454 ,  C07D403/12 ,  A61K31/4025 ,  A61K31/496 ,  C07D205/04 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/4453 ,  C07D211/22 ,  A61K31/40 ,  C07D207/14 ,  C07D207/12 ,  A61K31/138 ,  C07C215/20 ,  C07D413/14 ,  C07D213/82 ,  C07D491/08 ,  C07D417/14 ,  A61K31/541 ,  C07D471/08 ,  C07D405/12 ,  A61K31/135 ,  C07D213/80 ,  C07D207/16 ,  C07D265/30 ,  A61K31/5375 ,  A61K31/166 ,  C07C235/46 ,  C07D417/12 ,  A61K45/06

摘要： The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20150152113A1

公开(公告)日：2015-06-04

申请号：US14406029

申请日：2013-06-19

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Ronald J. Mattson ,  Zhaoxing Meng ,  Leatte R. Guernon

IPC分类号： C07D487/04 ,  C07D491/107

CPC分类号： C07D487/04 ,  C07D491/107

摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds modulate the mGluR2 receptor and may be useful for the treatment of various disorders of the central nervous system. Formula (I):

摘要翻译： 本公开内容通常涉及式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物调节mGluR2受体并且可用于治疗中枢神经系统的各种疾病。 式（I）：