公开(公告)号：US20240124417A1

公开(公告)日：2024-04-18

申请号：US17766483

申请日：2020-10-01

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Denis R. ST. LAURENT ,  Li-Qiang SUN ,  Zhiwei YIN ,  Katharine A. GRANT-YOUNG ,  Paul Michael SCOLA

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D401/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D401/12 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20150368267A1

公开(公告)日：2015-12-24

申请号：US14765910

申请日：2014-02-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao WANG ,  Zhongxing ZHANG ,  Zhiwei YIN ,  Li-Qiang SUN ,  Eric MULL ,  Qian ZHAO ,  Paul Michael SCOLA

IPC: C07D498/22 ,  A61K31/53 ,  C07D498/20 ,  A61K31/551 ,  C07D498/08 ,  A61K45/06 ,  C07D498/18

CPC classification number: C07D498/22 ,  A61K31/53 ,  A61K31/551 ,  A61K45/06 ,  C07D498/08 ,  C07D498/18 ,  C07D498/20

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof, are set forth, in addition to compositions and methods of using these compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 除了使用这些化合物的组合物和方法之外，还列举了式I化合物，包括其药学上可接受的盐。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20250154148A1

公开(公告)日：2025-05-15

申请号：US18759708

申请日：2024-06-28

Applicant: Bristol-Myers Squibb Company

Inventor： Brian Edward FINK ,  Pravin S. SHIRUDE ,  Amit Kumar CHATTOPADHYAY ,  Laxmi Narayan NANDA ,  Vishweshwaraiah BALIGAR ,  Balaji SESHADRI ,  T.G. Murali DHAR ,  Li-Qiang SUN ,  Zhizhen Barbara ZHENG ,  Manoranjan PANDA ,  Maximilian David PALKOWITZ ,  Sirish Kaushik LAKKARAJU ,  Moloy BANERJEE

IPC: C07D471/04 ,  A61K31/553 ,  A61P35/00

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

公开(公告)号：US20250163046A1

公开(公告)日：2025-05-22

申请号：US18759719

申请日：2024-06-28

Applicant: Bristol-Myers Squibb Company

Inventor： Brian Edward FINK ,  Pravin S. SHIRUDE ,  Amit Kumar CHATTOPADHYAY ,  Laxmi Narayan NANDA ,  Vishweshwaraiah BALIGAR ,  Balaji SESHADRI ,  T.G. Murali DHAR ,  Li-Qiang SUN ,  Zhizhen Barbara ZHENG ,  Manoranjan PANDA ,  Maximilian David PALKOWITZ ,  Sirish Kaushik LAKKARAJU ,  Moloy BANERJEE

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/5386 ,  A61K31/553 ,  A61K31/554 ,  A61P35/00 ,  C07D519/00

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

公开(公告)号：US20200172578A1

公开(公告)日：2020-06-04

申请号：US16624989

申请日：2018-06-21

Applicant: Bristol-Myers Squibb Company

Inventor： Kevin W. GILLMAN ,  Jason GOODRICH ,  Li-Qiang SUN ,  Eric MULL ,  David R. LANGLEY ,  Paul Michael SCOLA

IPC: C07K7/56

Abstract: The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 pro-tein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

公开(公告)号：US20220251141A1

公开(公告)日：2022-08-11

申请号：US17612915

申请日：2020-05-21

Applicant: Bristol-Myers Squibb Company

Inventor： Tao WANG ,  Li-Qiang SUN ,  Zhaoxing MENG ,  Paul SCOLA

IPC: C07K7/52

Abstract: In accordance with the present disclosure, macrocyclic compounds have been discovered that bind to PD-L1 and are capable of inhibiting the interaction of PD-L1 with PD-1 and CD80. These macrocyclic compounds exhibit in vitro immunomodulatory efficacy thus making them therapeutic candidates for the treatment of various diseases including cancer and infectious diseases.

公开(公告)号：US20190352280A1

公开(公告)日：2019-11-21

申请号：US16471531

申请日：2017-12-19

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun YEUNG ,  Katharine A. GRANT-YOUNG ,  Li-Qiang SUN ,  David R. LANGLEY ,  Denis R. ST. LAURENT ,  Paul M. SCOLA

IPC: C07D401/14 ,  C07D471/08 ,  C07D413/14

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.