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![1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor](/abs-image/US/2023/01/17/US11554120B2/abs.jpg.150x150.jpg)
公开(公告)号：US11554120B2
公开(公告)日：2023-01-17
申请号：US16527802
申请日：2019-07-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yam B. Poudel , Sanjeev Gangwar , Liqi He , Prasanna Sivaprakasam , Matthias Broekema , Matthew Cox , Christine M. Tarby , Qian Zhang , Naidu S. Chowdari
IPC: C07D487/04 , A61K31/519 , A61K47/60 , A61K39/395 , A61P35/00 , A61K31/395
Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.
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