专利检索 ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"Qian Zhang" 第 1 页

1.

发明授权
Immunoconjugates, compositions for making them, and methods of making and use 有权
标题翻译：免疫缀合物，制备它们的组合物，以及制备和使用方法

公开(公告)号：US09186416B2

公开(公告)日：2015-11-17

申请号：US14471096

申请日：2014-08-28

申请人： Bristol-Myers Squibb Company

发明人： Qian Zhang , Sanjeev Gangwar , Chin Pan , Daniel W. Derwin

IPC分类号： A61K47/48 , C07K5/06 , C07K5/10 , C07K5/08 , A61K31/404 , C07D403/06 , C07D403/14 , C07D209/60

CPC分类号： A61K47/48384 , A61K31/404 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , C07D209/60 , C07D403/06 , C07D403/14 , C07K5/06 , C07K5/06034 , C07K5/06095 , C07K5/08 , C07K5/0808 , C07K5/10

摘要： An immunoconjugate in which a phosphate-prodrugged DNA minor groove binding agent of formula (I), where X is a nucleophilically displaceable leaving group, is conjugated to an antibody or an antigen binding fragment of an antibody, and compounds that can be used for making such immunoconjugates, and uses of such immunoconjugates.

摘要翻译： 一种免疫偶联物，其中式（I）的磷酸酯前体化DNA小沟结合剂（其中X是可亲可取代的离去基团）与抗体或抗体的抗原结合片段缀合，以及可用于制备的化合物这样的免疫缀合物，以及这种免疫缀合物的用途。

2.

发明授权
1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor 有权

公开(公告)号：US11554120B2

公开(公告)日：2023-01-17

申请号：US16527802

申请日：2019-07-31

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Yam B. Poudel , Sanjeev Gangwar , Liqi He , Prasanna Sivaprakasam , Matthias Broekema , Matthew Cox , Christine M. Tarby , Qian Zhang , Naidu S. Chowdari

IPC分类号： C07D487/04 , A61K31/519 , A61K47/60 , A61K39/395 , A61P35/00 , A61K31/395

摘要： Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

3.

发明授权
Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use 有权

公开(公告)号：US10287291B2

公开(公告)日：2019-05-14

申请号：US15680424

申请日：2017-08-18

申请人： BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE

发明人： Fukang Yang , Qian Zhang , Lawrence B. Snyder , Sanjeev Gangwar , Dale L. Boger

IPC分类号： C07D487/04 , C07D519/00 , A61K31/407 , A61K31/437 , A61K47/68 , A61P35/00 , A61K39/00

摘要： seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.