公开(公告)号：US20220305144A1

公开(公告)日：2022-09-29

申请号：US17722628

申请日：2022-04-18

Applicant: Bristol-Myers Squibb Company

Inventor： David J. Donnelly ,  Erin Lee Cole ,  Richard Charles Burrell ,  Wesley A. Turley ,  Alban J. Allentoff ,  Michael Arthur Wallace ,  James Aaron Balog ,  Audris Huang ,  Mette Skinbjerg

IPC: A61K51/04 ,  C07B59/00 ,  C07D215/18 ,  G01N33/60

Abstract: The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.

公开(公告)号：US20240383871A1

公开(公告)日：2024-11-21

申请号：US18687356

申请日：2022-08-29

Applicant: Bristol-Myers Squibb Company

Inventor： David J. Donnelly ,  Alban J. Allentoff ,  Michael Arthur Wallace ,  Samuel J. Bonacorsi ,  Scot Watterson ,  Joseph A. Tino

IPC: C07D401/04 ,  A61K51/04 ,  C07B59/00

Abstract: Disclosed is a compound of Formula (Ib): The compound of Formula (Ib) is useful for positron emission tomography (PET) imaging of Bruton's Tyrosine Kinase (BTK) in mammals. Also disclosed are methods of using the compound as a labeling and diagnostic imaging agent of Bruton's Tyrosine Kinase (BTK), and methods of preparing Compound (Ib).

公开(公告)号：US20190282714A1

公开(公告)日：2019-09-19

申请号：US16318209

申请日：2017-07-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： David J. Donnelly ,  Erin Lee Cole ,  Richard Charles Burrell ,  Wesley A. Turley ,  Alban J. Allentoff ,  Michael Arthur Wallace ,  James Aaron Balog ,  Audris Huang ,  Mette Skinbjerg

IPC: A61K51/04 ,  C07D215/18 ,  C07B59/00

Abstract: The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.