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公开(公告)号：US20220305144A1
公开(公告)日：2022-09-29
申请号：US17722628
申请日：2022-04-18
发明人： David J. Donnelly , Erin Lee Cole , Richard Charles Burrell , Wesley A. Turley , Alban J. Allentoff , Michael Arthur Wallace , James Aaron Balog , Audris Huang , Mette Skinbjerg
IPC分类号： A61K51/04 , C07B59/00 , C07D215/18 , G01N33/60
摘要： The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.
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公开(公告)号：US11103605B2
公开(公告)日：2021-08-31
申请号：US16098765
申请日：2017-05-17
摘要： The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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公开(公告)号：US09987381B2
公开(公告)日：2018-06-05
申请号：US15032486
申请日：2014-10-31
发明人： Thomas Jon Seiders , David J. Donnelly , Samuel J. Bonacorsi, Jr. , Kai Cao , Tritin Tran , Adrienne Pena , Joonyoung Kim , Richard E. Carson , Nabeel Nabulsi , Jean-Dominique Gallezot , Yiyun Huang , Jeffrey Roger Roppe
IPC分类号： A61K51/04 , C07D261/14 , C07B59/00 , A61B6/00
CPC分类号： A61K51/0453 , A61B6/481 , C07B59/002 , C07B2200/05 , C07D261/14
摘要： The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.
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公开(公告)号：US20160256577A1
公开(公告)日：2016-09-08
申请号：US15032486
申请日：2014-10-31
发明人： Thomas Jon Seiders , David J. Donnelly , Samuel J. Bonacorsi, JR. , Kai Cao , Tritin Tran , Adrienne Pena , Joonyoung Kim , Richard E. Carson , Nabel Nabulsi , Jean-Dominique Gallezot , Yiyun Huang , Jeffrey Roger Roppe
IPC分类号： A61K51/04 , A61B6/00 , C07D261/14
CPC分类号： A61K51/0453 , A61B6/481 , C07B59/002 , C07B2200/05 , C07D261/14
摘要： The present invention relates to radiolabeled LPA1 receptor antagonists or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of LPA1 receptors in mammals.
摘要翻译： 本发明涉及放射性标记的LPA1受体拮抗剂或其药学上可接受的盐，其可用于哺乳动物中LPA1受体的定量成像。
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公开(公告)号：US20210379210A1
公开(公告)日：2021-12-09
申请号：US17285194
申请日：2019-10-14
发明人： Peter Tai Wah Cheng , James R. Corte , David J. Donnelly , Joonyoung Kim , Jun Shi , Shiwei Tao , Tritin Tran
IPC分类号： A61K51/04 , C07D401/04
摘要： The present invention relates to radiolabeled LPA1 receptor antagonists of Formula (I) or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein, which are useful for the quantitative imaging of LPA1 receptors in mammals.
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公开(公告)号：US20190282714A1
公开(公告)日：2019-09-19
申请号：US16318209
申请日：2017-07-18
发明人： David J. Donnelly , Erin Lee Cole , Richard Charles Burrell , Wesley A. Turley , Alban J. Allentoff , Michael Arthur Wallace , James Aaron Balog , Audris Huang , Mette Skinbjerg
IPC分类号： A61K51/04 , C07D215/18 , C07B59/00
摘要： The present invention relates to radiolabeled IDO1 inhibitors or pharmaceutically acceptable salts thereof which are useful for the quantitative imaging of IDO enzymes in mammals.
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公开(公告)号：US20190117801A1
公开(公告)日：2019-04-25
申请号：US16098765
申请日：2017-05-17
摘要： The invention relates to the synthesis and use of 18F-labeled millamolecules for imaging various processes within the body, for detecting the location of molecules associated with disease pathology, and for monitoring disease progression are disclosed.
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