公开(公告)号：US20180162889A1

公开(公告)日：2018-06-14

申请号：US15838434

申请日：2017-12-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Michael G. YANG ,  Zili Xiao ,  John V. Duncia ,  David S. Weinstein

IPC: C07F9/6558 ,  C07F9/6509 ,  A61P37/00 ,  A61P29/00

CPC classification number: C07F9/65583 ,  A61K31/50 ,  A61K31/501 ,  A61P29/00 ,  A61P37/00 ,  C07D237/24 ,  C07D401/12 ,  C07F9/650905

Abstract: Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.