公开(公告)号：US20180222883A1

公开(公告)日：2018-08-09

申请号：US15887214

申请日：2016-08-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Hai-Yun XIAO ,  Murali T.G. Dhar ,  Ning Li ,  Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu ,  Khehyong Ngu ,  William J. Pitts ,  Joseph A. Tino

IPC: C07D401/04 ,  C07D215/44 ,  C07D215/42 ,  C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

CPC classification number: C07D401/04 ,  C07D215/42 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.