公开(公告)号：US11623921B2

公开(公告)日：2023-04-11

申请号：US17110643

申请日：2020-12-03

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qingjie Liu ,  Scott Hunter Watterson ,  John E. Macor ,  Khehyong Ngu ,  Saleem Ahmad

IPC: C07D417/04 ,  C07D401/10 ,  C07D403/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D209/18 ,  A61P29/00 ,  A61P37/00 ,  C07D209/08

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20220402950A1

公开(公告)日：2022-12-22

申请号：US17265844

申请日：2019-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Daniel S. Gardner ,  John V. Duncia ,  Joseph B. Santella ,  Khehyong Ngu ,  Christopher Annunziato

IPC: C07F9/6561 ,  C07D471/08 ,  C07D401/14 ,  A61K45/06

Abstract: The present invention provides compounds of Formula (I): useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.

公开(公告)号：US11524959B1

公开(公告)日：2022-12-13

申请号：US17265842

申请日：2019-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Anurag S. Srivastava ,  Robert J. Cherney ,  Khehyong Ngu

IPC: C07D471/04 ,  A61K31/437 ,  C07D471/08 ,  A61K45/06 ,  C07D519/00

Abstract: The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, wherein each of Ring A, L, Q, R1, R2, R3, R4, R7, and R8 along with other variables are as defined herein.

公开(公告)号：US10604504B2

公开(公告)日：2020-03-31

申请号：US16396879

申请日：2019-04-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qingjie Liu ,  Scott Hunter Watterson ,  John E. Macor ,  Khehyong Ngu ,  Saleem Ahmad

IPC: A61K31/436 ,  A61P35/04 ,  C07D401/10 ,  C07D403/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D209/18 ,  A61P29/00 ,  A61P37/00 ,  C07D209/08

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20210107891A1

公开(公告)日：2021-04-15

申请号：US17110643

申请日：2020-12-03

Applicant: Bristol-Myers Squibb Company

Inventor： QINGJIE LIU ,  Scott Hunter Watterson ,  John E. Macor ,  Khehyong Ngu ,  Saleem Ahmad

IPC: C07D401/10 ,  C07D403/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10 ,  C07D209/18 ,  A61P29/00 ,  A61P37/00 ,  C07D209/08

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20190248760A1

公开(公告)日：2019-08-15

申请号：US16396879

申请日：2019-04-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qingjie LIU ,  Scott Hunter Watterson ,  John E. Macor ,  Khehyong Ngu ,  Saleem Ahmad

IPC: C07D401/10 ,  A61P37/00 ,  C07D403/12 ,  C07D209/08 ,  C07D209/18 ,  C07D487/10 ,  C07D487/04 ,  C07D471/04 ,  C07D417/04 ,  C07D413/04 ,  C07D403/10 ,  C07D403/04 ,  C07D401/12 ,  C07D401/06 ,  C07D401/04 ,  A61P29/00

CPC classification number: C07D401/10 ,  A61P29/00 ,  A61P37/00 ,  C07D209/08 ,  C07D209/18 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

公开(公告)号：US20240199584A1

公开(公告)日：2024-06-20

申请号：US18450847

申请日：2023-08-16

Applicant: Bristol-Myers Squibb Company

Inventor： Brian Edward Fink ,  Khehyong Ngu ,  Pravin S. Shirude ,  Manoranjan Panda ,  Prasada Rao Jalagam ,  Laxmi Narayan Nanda ,  Vishweshwaraiah Baligar ,  Balaji Seshadri ,  Excel Merlin Soosairaj ,  Maximilian David Palkowitz ,  Amit Kumar Chattopadhyay

IPC: C07D403/12 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

CPC classification number: C07D403/12 ,  A61K31/498 ,  A61K31/4985 ,  A61P35/00 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

Abstract: The present disclosure provides KRAS inhibitors. Methods of treating cancers using the compounds are also provided.

公开(公告)号：US20180222883A1

公开(公告)日：2018-08-09

申请号：US15887214

申请日：2016-08-02

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Hai-Yun XIAO ,  Murali T.G. Dhar ,  Ning Li ,  Jingwu Duan ,  Bin Jiang ,  Zhonghui Lu ,  Khehyong Ngu ,  William J. Pitts ,  Joseph A. Tino

IPC: C07D401/04 ,  C07D215/44 ,  C07D215/42 ,  C07D401/14 ,  C07D401/12 ,  C07D413/14 ,  C07D405/14 ,  C07D417/12 ,  C07D413/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

CPC classification number: C07D401/04 ,  C07D215/42 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: A is CR1 or N; B is CR3 or N; D is CR4 or N; L1 is —(CR7R7)m—; L2 is —(CR7R7)n—; and X, Z, R1, R2, R3, R4, R5, and R6 are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20160115126A1

公开(公告)日：2016-04-28

申请号：US14921347

申请日：2015-10-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Qingjie Liu ,  Scott Hunter Watterson ,  Douglas G. Batt ,  Saleem Ahmad ,  Myra Beaudoin Bertrand ,  Hua Gong ,  Weiwei Guo ,  John E. Macor ,  Khehyong Ngu ,  Andrew J. Tebben ,  Joseph A. Tino

IPC: C07D209/08 ,  C07D403/10 ,  C07D403/12 ,  C07D403/04 ,  C07D487/10 ,  C07D487/04 ,  C07D413/04 ,  C07D471/04 ,  C07D401/06 ,  C07D417/04 ,  C07D401/04 ,  C07D401/12

CPC classification number: C07D401/10 ,  C07D209/08 ,  C07D209/18 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D403/04 ,  C07D403/10 ,  C07D403/12 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/10

Abstract: Disclosed are compounds of Formula (I): or a salt thereof, wherein: X is CR4 or N; R1, R2, R3, R4, and A are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

Abstract translation: 公开了式（I）的化合物或其盐，其中：X是CR 4或N; R1，R2，R3，R4和A在本文中定义。 还公开了使用这种化合物作为Bruton酪氨酸激酶（Btk）的抑制剂的方法和包含这些化合物的药物组合物。 这些化合物可用于治疗，预防或减缓各种治疗领域（例如自身免疫性疾病和血管疾病）中的疾病或病症的进展。

公开(公告)号：US20230203039A1

公开(公告)日：2023-06-29

申请号：US17760309

申请日：2021-02-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Khehyong Ngu ,  Christopher Annunziato ,  John V. Duncia ,  Daniel Gardner

IPC: C07D471/22 ,  C07D498/22 ,  C07D487/22 ,  C07D519/00 ,  A61K45/06

CPC classification number: C07D471/22 ,  C07D498/22 ,  C07D487/22 ,  C07D519/00 ,  A61K45/06

Abstract: The present invention provides compounds of Formula (I) useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders, (I) wherein ring A, A1, A2, A3, A4, Q, R1, R2, R3, R4, R5, and R6 along with other variables are as defined herein.