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1.发明申请POSITIVE ALLOSTERIC MODULATORS AND SILENT ALLOSTERIC MODULATORS OF THE Mu OPIOID RECEPTOR 有权阳性受体受体的阳性调节因子和沉默寡核苷酸调节因子公开(公告)号：US20150338404A1
公开(公告)日：2015-11-26
申请号：US14758908
申请日：2013-12-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Neil Burford , Andrew Alt
IPC: G01N33/566
CPC classification number: G01N33/566 , G01N2333/705 , G01N2333/726 , G01N2500/10
Abstract: Disclosed are positive allosteric modulators (PAMs) and silent allosteric modulators (SAMs) for mu (μ)-opioid receptors that may be useful for the treatment of pain, either alone or in combination with orthosteric opioid receptor agonists. Methods for treating pain and modulating mu (μ)-opioid receptors are also disclosed.
Abstract translation: 公开了用于mu（μ） - 阿片样受体的阳性变构调节剂（PAM）和沉默变构调节剂（SAM），其可用于治疗疼痛，单独或与正常阿片受体激动剂组合。 还公开了治疗疼痛和调节μ（μ） - 阿片受体的方法。
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2.发明授权公开(公告)号：US09784740B2
公开(公告)日：2017-10-10
申请号：US14758908
申请日：2013-12-20
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Neil Burford , Andrew Alt
IPC: G01N33/566
CPC classification number: G01N33/566 , G01N2333/705 , G01N2333/726 , G01N2500/10
Abstract: Disclosed are positive allosteric modulators (PAMs) and silent allosteric modulators (SAMs) for mu (μ)-opioid receptors that may be useful for the treatment of pain, either alone or in combination with orthosteric opioid receptor agonists. Methods for treating pain and modulating mu (μ)-opioid receptors are also disclosed.
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