公开(公告)号：US20190233449A1

公开(公告)日：2019-08-01

申请号：US16318173

申请日：2017-07-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter T.W. CHENG ,  Wei Meng ,  Mark Liu ,  Bei Wang ,  Rulin Zhao

IPC: C07F9/6571 ,  A61P3/10

CPC classification number: C07F9/657181 ,  A61P3/10 ,  C07B2200/13

Abstract: A compound, enantiomer, prodrug, diastereomer, or salt is provided which is an activator of the enzyme glucokinase and thus is believed to be useful in as treating diabetes and related diseases, which compound has the structure (I). A method for treating diabetes and related disease employing the compound, enantiomer, prodrug, diastereomer, or salt is also provided.

公开(公告)号：US20150191494A1

公开(公告)日：2015-07-09

申请号：US14661063

申请日：2015-03-18

Applicant: Bristol-Myers Squibb Company ,  Albany Molecular Research, Inc.

Inventor： Paul Lobben ,  Rulin Zhao ,  Bei Wang ,  Bang-Chi Chen ,  Shuang Liu ,  Min Hu ,  Yuh-Lin Allen Yang ,  Matthew Isherwood ,  Rasidul Amin ,  Wenge Cui

IPC: C07F5/04 ,  C07C217/58 ,  C07C215/20 ,  C07D413/10 ,  C07F5/02 ,  C07D237/20 ,  C07D401/04 ,  C07C223/02 ,  C07D217/04

CPC classification number: C07F5/04 ,  C07C215/20 ,  C07C217/58 ,  C07C223/02 ,  C07D217/04 ,  C07D237/20 ,  C07D401/04 ,  C07D413/10 ,  C07F5/022 ,  C07F5/025

Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.

Abstract translation: 公开了制备四氢异喹啉的方法，可用于制备四氢异喹啉的中间体，制备这种中间体的方法和6 - [（4S）-2-甲基-4-（萘基）-1,2,3,4 - 四氢异喹啉-7-基]哒嗪-3-胺。 还公开了包含四氢异喹啉的药物组合物，使用四氢异喹啉处理抑郁症和其它病症的方法以及获得结晶形式的方法。

公开(公告)号：US10604541B2

公开(公告)日：2020-03-31

申请号：US16318173

申请日：2017-07-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Wei Meng ,  Mark Liu ,  Bei Wang ,  Rulin Zhao

IPC: C07F9/40 ,  A61K31/675 ,  A61P3/00 ,  C07F9/6571 ,  A61P3/10

Abstract: A compound, enantiomer, prodrug, diastereomer, or salt is provided which is an activator of the enzyme glucokinase and thus is believed to be useful in as treating diabetes and related diseases, which compound has the structure (I). A method for treating diabetes and related disease employing the compound, enantiomer, prodrug, diastereomer, or salt is also provided.

公开(公告)号：US20130060027A1

公开(公告)日：2013-03-07

申请号：US13664546

申请日：2012-10-31

Applicant: Bristol-Myers Squibb Company

Inventor： Paul Lobben ,  Rulin Zhao ,  Bei Wang ,  Bang-Chi Chen ,  Shuang Liu ,  Min Hu ,  Yuh-Lin Yang ,  Matthew Isherwood ,  Rasidul Amin ,  Wenge Cui

IPC: C07D401/10

CPC classification number: C07F5/04 ,  C07C215/20 ,  C07C217/58 ,  C07C223/02 ,  C07D217/04 ,  C07D237/20 ,  C07D401/04 ,  C07D413/10 ,  C07F5/022 ,  C07F5/025

Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.