公开(公告)号：US20160280649A1

公开(公告)日：2016-09-29

申请号：US15034915

申请日：2014-01-16

Applicant: Bristol-Myers Squibb Company

Inventor： Ryan M. MOSLIN ,  David S. WEINSTEIN ,  Stephen T. WROBLESKI ,  Yanlei ZHANG ,  John S. TOKARSKI ,  Michael E. MERTZMAN ,  Chunjian LIU

IPC: C07D213/82 ,  C07D417/12 ,  C07D413/12 ,  C07B59/00 ,  C07D405/12 ,  C07D401/12

CPC classification number: A61K31/455 ,  A61K31/44 ,  A61K31/444 ,  A61K31/506 ,  C07B59/002 ,  C07B2200/05 ,  C07D213/56 ,  C07D213/82 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: Compounds having the following formula (I): or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα by acting on Tyk-2 to cause signal transduction inhibition.

Abstract translation: 具有下式（I）的化合物或其立体异构体或其药学上可接受的盐，其中R 1，R 2，R 3，R 4和R 5如本文所定义，可用于调节IL-12，IL-23和 /或IFNa作用于Tyk-2以引起信号转导抑制。

公开(公告)号：US20180111937A1

公开(公告)日：2018-04-26

申请号：US15558708

申请日：2016-03-17

Applicant: Bristol-Myers Squibb Company

Inventor： Stephen T. WROBLESKI ,  Gregory D. BROWN ,  Shuqun LIN ,  Jingwu DUAN ,  Zhonghui LU ,  Murali T.G. DHAR ,  Hai-Yun XIAO ,  Andrew J. TEBBEN

IPC: C07D471/14 ,  A61P29/00 ,  A61P37/00 ,  C07D491/147

CPC classification number: C07D471/14 ,  A61P29/00 ,  A61P37/00 ,  C07D487/06 ,  C07D491/147

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is N; W is: —(CR3R3)2-5-, —(CR3R3)x-Y—(CR3R3)y-, —Y—(CR3R3)2-3-Y—, —CR3R3-Y—(CR3R3)2-Y—, —Y—(CR3R3)2-Y—CR3R3-; and Y, R1, R2, R3, R5, R6, R8, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20180072728A1

公开(公告)日：2018-03-15

申请号：US15558724

申请日：2016-03-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Lawrence R. MARCIN ,  Stephen T. WROBLESKI ,  Murali T.G. DHAR

IPC: C07D471/14

CPC classification number: C07D471/14

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein: X is CR6 or N; W is: (i) —(CR3R3)1-4— or (ii) —(CR3R3)x-Y—(CR3R3)y-; and Y, R1, R2, R3, R5, R6, R7, x, and y are define herein. Also disclosed are methods of using such compounds as modulators of TNFα, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.