公开(公告)号：US20140193422A1

公开(公告)日：2014-07-10

申请号：US14211438

申请日：2014-03-14

Applicant: Bristol-Myers Squibb Company

Inventor： Maria Jure-Kunkel ,  Laura J. Hefta ,  Marc Santoro ,  Subinay Ganguly ,  Edward L. Halk

IPC: C07K16/30

CPC classification number: C07K16/2878 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92 ,  C12N2740/15034 ,  A61K2300/00

Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.

Abstract translation: 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。

公开(公告)号：US20160368998A1

公开(公告)日：2016-12-22

申请号：US15174268

申请日：2016-06-06

Applicant: Bristol-Myers Squibb Company

Inventor： Maria JURE-KUNKEL ,  Laura J. Hefta ,  Marc Santoro ,  Subinay Ganguly ,  Edward L. Halk

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92 ,  C12N2740/15034 ,  A61K2300/00

Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.

Abstract translation: 与人4-1BB结合并允许人4-1BB与人4-1BB配体结合的完全人抗体及其抗原结合部分。 一方面，抗体是IgG4抗体。 还提供了治疗受试者疾病的方法，包括向所述受试者施用治疗有效量的抗体。

公开(公告)号：US20190062445A1

公开(公告)日：2019-02-28

申请号：US16136876

申请日：2018-09-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Maria Jure-Kunkel ,  Laura J. Hefta ,  Marc Santoro ,  Subinay Ganguly ,  Edward L. Halk

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/30 ,  A61K39/39 ,  A61K39/12

Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.

公开(公告)号：US09382328B2

公开(公告)日：2016-07-05

申请号：US14211438

申请日：2014-03-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Maria Jure-Kunkel ,  Laura J. Hefta ,  Marc Santoro ,  Subinay Ganguly ,  Edward L. Halk

IPC: C07K16/28 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39

CPC classification number: C07K16/2878 ,  A61K39/0011 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/505 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92 ,  C12N2740/15034 ,  A61K2300/00

Abstract: Fully human antibodies and antigen-binding portions thereof that bind to human 4-1BB and that allow binding of human 4-1BB to a human 4-1BB ligand. In one aspect, the antibody is an IgG4 antibody. Also provided is a method for treating a disease in a subject comprising administering a therapeutically effective amount of the antibody to said subject.