公开(公告)号：US20170233436A1

公开(公告)日：2017-08-17

申请号：US15587715

申请日：2017-05-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Ivar M. MCDONALD ,  Naidu S. CHOWDARI ,  Tram N. HUYNH ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR

IPC: C07K5/062

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

公开(公告)号：US20180079781A1

公开(公告)日：2018-03-22

申请号：US15785675

申请日：2017-10-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yong ZHANG ,  Ivar M. MCDONALD ,  Naidu S. CHOWDARI ,  Tram N. HUYNH ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR

IPC: C07K5/062

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

公开(公告)号：US20170073357A1

公开(公告)日：2017-03-16

申请号：US15351843

申请日：2016-11-15

Applicant: Bristol-Myers Squibb Company

Inventor： Yong ZHANG ,  Ivar M. MCDONALD ,  Naidu S. CHOWDARI ,  Tram N. HUYNH ,  Robert M. BORZILLERI ,  Sanjeev GANGWAR

IPC: C07D519/00

CPC classification number: C07K5/06052 ,  A61K47/6843 ,  A61K47/6849 ,  C07D487/04 ,  C07D519/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  C07K2317/76

Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).

Abstract translation: 其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。