-
1.发明申请公开(公告)号：US20180037581A1
公开(公告)日：2018-02-08
申请号：US15785608
申请日：2017-10-17
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61K47/68 , C07K5/062
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
-
公开(公告)号：US20180243312A1
公开(公告)日：2018-08-30
申请号：US15755636
申请日：2016-08-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Robert M. BORZILLERI , Brian E. Fink , Lalgudi S. Harikrishnan , Jayakumar Sankara Warrier
CPC classification number: A61K31/53 , A61K35/02 , A61K2121/00 , A61P35/00 , C07D487/04 , C07D519/00
Abstract: The invention relates generally to compounds that modulate the activity of TGFBETA R-1 and TGFBETA R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
-
公开(公告)号：US20170233436A1
公开(公告)日：2017-08-17
申请号：US15587715
申请日：2017-05-05
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07K5/062
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
-
4.发明申请公开(公告)号：US20160376288A1
公开(公告)日：2016-12-29
申请号：US15189388
申请日：2016-06-22
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Robert M. BORZILLERI , Andrew J. TEBBEN , Erik M. STANG , Andrew F. DONNELL , Gretchen M. SCHROEDER , Heidi L. PEREZ , Donna D. WEI
IPC: C07D498/22 , C07K16/30 , A61K47/48
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
Abstract translation: 并且式I，Ia和Ib中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是用作抗体 - 药物偶联物（ADC）中的药物成分时。
-
公开(公告)号：US20160130299A1
公开(公告)日：2016-05-12
申请号：US14833422
申请日：2015-08-24
Applicant: Bristol-Myers Squibb Company
Inventor： Heidi L. PEREZ , Donna WEI , Robert M. BORZILLERI , Sanjeev GANGWAR , Gretchen M. SCHROEDER , Heng CHENG , Robert J. SCHMIDT
CPC classification number: C07K5/06139 , A61K47/48438 , A61K47/48569 , A61K47/48715 , A61K47/6817 , A61K47/6851 , A61K47/6889 , C07K5/06026 , C07K5/06034 , C07K5/06052 , C07K16/3038 , C07K16/3046
Abstract: Tubulysin analogs of the formula (I) where R1, R2 R3, R4, R5, R6, R7, and Y are as defined herein, are anti-mitotic agents that can be used in the treatment of cancer, especially when conjugated to a targeting moiety.
Abstract translation: 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和Y如本文所定义的式（I）的妥布林类似物是可用于治疗癌症的抗有丝分裂剂，特别是当与靶向缀合时 部分。
-
Patent Agency Ranking
公开(公告)号：US20180079781A1
公开(公告)日：2018-03-22
申请号：US15785675
申请日：2017-10-17
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07K5/062
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
-
公开(公告)号：US20170260205A1
公开(公告)日：2017-09-14
申请号：US15606512
申请日：2017-05-26
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Yong ZHANG , Robert M. BORZILLERI , Andrew J. TEBBEN , Erik STANG , Andrew F. DONNELL , Gretchen M. SCHROEDER , Heidi L. PEREZ , Donna D. WEI
IPC: C07D498/22 , A61K31/5517 , A61K31/5513 , C07K16/30 , C07D519/00
CPC classification number: C07D498/22 , A61K31/5513 , A61K31/5517 , A61K47/48384 , A61K47/48569 , A61K47/48592 , A61K47/48615 , A61K47/48638 , A61K47/48715 , A61K47/6801 , A61K47/6803 , A61K47/6851 , A61K47/6857 , A61K47/6859 , A61K47/6863 , A61K47/6869 , A61K47/6889 , C07D519/00 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K16/3069
Abstract: Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).
-
8.发明申请公开(公告)号：US20170073357A1
公开(公告)日：2017-03-16
申请号：US15351843
申请日：2016-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Yong ZHANG , Ivar M. MCDONALD , Naidu S. CHOWDARI , Tram N. HUYNH , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D519/00
CPC classification number: C07K5/06052 , A61K47/6843 , A61K47/6849 , C07D487/04 , C07D519/00 , C07K16/18 , C07K16/28 , C07K16/30 , C07K2317/76
Abstract: Benzodiazepine dimers having a structure represented by wherein R1 is wherein the variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 其中式（I），（Ia）和（Ib）中的变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
-
公开(公告)号：US20180215761A1
公开(公告)日：2018-08-02
申请号：US15746597
申请日：2016-07-21
Applicant: Bristol-Myers Squibb Company
Inventor： Lalgudi S. HARIKRISHNAN , Brian E. FINK , Robert M. BORZILLERI , Gopikishan TONUKUNURU , Hasibur RAHAMAN , Jayakumar SANKARA WARRIER , Balaji SESHADRI
IPC: C07D487/04 , A61K31/541 , A61K31/53
CPC classification number: C07D487/04 , A61K31/53 , A61K31/541
Abstract: The invention relates generally to compounds that modulate the activity of TGFβR-1 and TGFβ R-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
-
10.发明申请HETEROARYLENE-BRIDGED BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING 有权异丁烯二苯并二恶英二聚体，其结合物及其制备和使用方法公开(公告)号：US20170057959A1
公开(公告)日：2017-03-02
申请号：US15351955
申请日：2016-11-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ivar M. MCDONALD , Naidu S. CHOWDARI , Walter Lewis JOHNSON , Yong ZHANG , Robert M. BORZILLERI , Sanjeev GANGWAR
IPC: C07D471/04
CPC classification number: C07D471/04 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07D487/04 , C07D519/00 , C07K5/06052
Abstract: Benzodiazepine dimers having a structure represented by wherein X comprises a heteroaromatic moiety and is as further defined in the application; R1 is and the other variables in formulae (I), (Ia), and (Ib) are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used in an antibody-drug conjugate (ADC).
Abstract translation: 并且式（I），（Ia）和（Ib）中的其它变量如本申请中所定义。 这种二聚体可用作抗癌剂，特别是当用于抗体 - 药物偶联物（ADC）时。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.025 seconds)
