公开(公告)号：US20070185047A1

公开(公告)日：2007-08-09

申请号：US11565785

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having an alternating motif and another strand having a hemimer motif, a blockmer motif, a fully modified motif or a positionally modified motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070167392A1

公开(公告)日：2007-07-19

申请号：US11565858

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070179109A1

公开(公告)日：2007-08-02

申请号：US11565839

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070172948A1

公开(公告)日：2007-07-26

申请号：US11565833

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00 ,  C07H21/04

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20050130923A1

公开(公告)日：2005-06-16

申请号：US10946147

申请日：2004-09-20

申请人： Balkrishen Bhat ,  Prasad Dande ,  Thazha Prakash ,  Charles Allerson ,  Eric Swayze ,  Richard Griffey

发明人： Balkrishen Bhat ,  Prasad Dande ,  Thazha Prakash ,  Charles Allerson ,  Eric Swayze ,  Richard Griffey

IPC分类号： A61K31/675 ,  A61K48/00 ,  C12N15/113 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/32

摘要： The present invention provides modified oligomeric compounds and compositions of oligomeric compounds for use in the RNA interference pathway of gene modulation. The modified oligomeric compounds include siRNA and asRNA having at least one affinity modification.

摘要翻译： 本发明提供用于基因调控的RNA干扰途径的改性寡聚化合物和低聚化合物的组合物。 修饰的寡聚化合物包括具有至少一个亲和力修饰的siRNA和asRNA。

公开(公告)号：US20070185046A1

公开(公告)日：2007-08-09

申请号：US11565781

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having an alternating motif and another strand having a hemimer motif, a blockmer motif, a fully modified motif or a positionally modified motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070179106A1

公开(公告)日：2007-08-02

申请号：US11565799

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070173475A1

公开(公告)日：2007-07-26

申请号：US11565804

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070167391A1

公开(公告)日：2007-07-19

申请号：US11565841

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00 ,  C07H21/02

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.

公开(公告)号：US20070179108A1

公开(公告)日：2007-08-02

申请号：US11565823

申请日：2006-12-01

申请人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

发明人： Balkrishen Bhat ,  Thazha Prakash ,  Prasad Dande ,  Charles Allerson ,  Richard Griffey ,  Eric Swayze

IPC分类号： A61K48/00

CPC分类号： C12N15/113 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2320/30 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention provides double stranded compositions wherein each strand is modified to have a motif defined by positioning of β-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.