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公开(公告)号：US20070098722A1
公开(公告)日：2007-05-03
申请号：US10584292
申请日：2004-12-21
IPC分类号： A61K39/395 , A61K38/17
CPC分类号： C07K16/18 , A01K67/0275 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K2039/505 , C07K14/4737 , C12N15/8509
摘要： The use of inhibitors of long pentraxin PTX3 for the preparation of a medicament for the prevention and treatment of autoimmune diseases and of degenerative diseases of bone and cartilage is described.
摘要翻译： 描述了使用长五聚蛋白PTX3的抑制剂制备用于预防和治疗自身免疫疾病和骨和软骨退行性疾病的药物。
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2.发明申请Medicament comprising ptx3, alone or in combination with tsg-6, for treating degenerative diseases of cartilage and bone and treating female infertility 审中-公开包含单独或与tsg-6组合的ptx3的药物用于治疗软骨和骨的退行性疾病并治疗女性不育症公开(公告)号：US20070191269A1
公开(公告)日：2007-08-16
申请号：US10584295
申请日：2004-12-21
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The use of pentraxin PTX3 and of its combination with TSG-6 for the preparation of a medicament for the treatment of bone or cartilage diseases and for the treatment of female infertility is described.
摘要翻译： 描述了使用pentraxin PTX3及其与TSG-6的组合来制备用于治疗骨或软骨疾病和治疗女性不孕症的药物。
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公开(公告)号：US08003109B2
公开(公告)日：2011-08-23
申请号：US11882180
申请日：2007-07-31
IPC分类号： A61K39/00
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/47 , C07K14/71 , Y02A50/481
摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumor diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumors.
摘要翻译： 描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。
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公开(公告)号：US20080015153A1
公开(公告)日：2008-01-17
申请号：US11882180
申请日：2007-07-31
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/47 , C07K14/71 , Y02A50/481
摘要： Pharmaceutical compositions are described containing a long pentraxin PTX3, particularly human PTX3, for the therapy of infectious and inflammatory or tumour diseases; expression vectors containing cDNA coding for PTX3; recombinant host cells transfected with such vectors; a method for producing substantial amounts of PTX3 involving the culturing of such cells, and the use of said vectors in the gene therapy of tumours.
摘要翻译： 描述的药物组合物含有长的pentraxin PTX3，特别是人PTX3，用于治疗感染性和炎性或肿瘤疾病; 含有编码PTX3的cDNA的表达载体; 用这些载体转染的重组宿主细胞; 用于生产涉及培养这种细胞的大量PTX3的方法，以及所述载体在肿瘤基因治疗中的用途。
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5.发明授权Use of the long pentraxin PTX3 for the treatment of diseases caused by an altered activation of the growth factor FGF-2 有权使用长的pentraxin PTX3用于治疗由生长因子FGF-2的活化改变引起的疾病公开(公告)号：US07858577B2
公开(公告)日：2010-12-28
申请号：US10416225
申请日：2001-11-08
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K38/1709 , A61K48/00 , A61K2300/00
摘要： The use of the long pentraxin PTX3 (PTX3) or one of its functional derivatives is described for the preparation of medicament which inhibits the biological activity of the growth factor FGF-2, useful for the prevention and treatment of diseases brought about by an altered activation of said growth factor FGF-2.
摘要翻译： 描述了使用长五倍体PTX3（PTX3）或其功能性衍生物之一用于制备抑制生长因子FGF-2的生物活性的药物，其可用于预防和治疗由改变的活化引起的疾病 的所述生长因子FGF-2。
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6.发明申请Use of long pentraxin ptx3 for the treatment of fgf-8 mediated tumour diseases 审中-公开使用长五倍素ptx3治疗fgf-8介导的肿瘤疾病公开(公告)号：US20050043230A1
公开(公告)日：2005-02-24
申请号：US10492130
申请日：2003-04-04
CPC分类号： A61K38/1709 , A61K2300/00
摘要： The use is described of the long pentraxin PTX3 (PTX3) or one of its functional derivatives as an agent inhibiting the activity of growth factor FGF-8, for the preparation of a medicine for the treatment of tumour diseases associated with abnormal activation of growth factor FGF-8.
摘要翻译： 描述了使用长五倍体PTX3（PTX3）或其功能衍生物之一作为抑制生长因子FGF-8活性的药剂，用于制备用于治疗与生长因子异常活化相关的肿瘤疾病的药物 FGF-8。
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公开(公告)号：US20110300171A1
公开(公告)日：2011-12-08
申请号：US13063458
申请日：2009-09-14
IPC分类号： A61K39/095 , A61P37/04 , A61P31/04 , A61K39/00
CPC分类号： A61K39/095
摘要： The invention relates to immunization against pathogenic bacterial strains which express or can express multiple factor H binding proteins. Certain aspects of the invention include vaccine compositions comprising at least two factor H binding proteins derived from a pathogenic bacterial strain which expresses multiple facto H binding proteins.
摘要翻译： 本发明涉及对表达或表达多因子H结合蛋白的致病性细菌菌株的免疫。 本发明的某些方面包括疫苗组合物，其包含至少两种衍生自表达多个事实H结合蛋白的病原菌菌株的因子H结合蛋白。
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