公开(公告)号：US20070072861A1

公开(公告)日：2007-03-29

申请号：US11387554

申请日：2006-03-23

申请人： Barbara Roniker ,  Richard LaChapelle ,  Daniel Connolly ,  Karen Seibert ,  Philip Needleman

发明人： Barbara Roniker ,  Richard LaChapelle ,  Daniel Connolly ,  Karen Seibert ,  Philip Needleman

IPC分类号： A61K31/50 ,  A61K31/4439 ,  A61K31/415 ,  A61K31/421 ,  A61K31/42 ,  A61K31/401 ,  A61K31/366 ,  A61K31/365 ,  A61K31/22

CPC分类号： A61K45/06 ,  A61K31/22 ,  A61K31/365 ,  A61K31/366 ,  A61K31/401 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/4439 ,  A61K31/50 ,  A61K2300/00

摘要： This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing cardiovascular disorders.

摘要翻译： 本发明涉及环氧合酶-2抑制剂或其衍生物在预防心血管疾病中的应用。

公开(公告)号：US06747020B2

公开(公告)日：2004-06-08

申请号：US10077134

申请日：2002-02-15

申请人： Alfonzo T. Perez ,  Debra J. Asner ,  Richard J. LaChapelle ,  John C. Alexander ,  Barbara Roniker

发明人： Alfonzo T. Perez ,  Debra J. Asner ,  Richard J. LaChapelle ,  John C. Alexander ,  Barbara Roniker

IPC分类号： A61R31585

CPC分类号： A61K45/06 ,  A61K31/401 ,  A61K31/585 ,  A61K31/7048 ,  A61K38/05 ,  A61K38/556 ,  A61K2300/00

摘要： Methods of using eplerenone, an angiotensin converting enzyme inhibitor and optionally a diuretic are described for treatment of heart failure and hypertension.

摘要翻译： 描述了使用依普利酮，血管紧张素转换酶抑制剂和任选的利尿剂来治疗心力衰竭和高血压的方法。

公开(公告)号：US20070191324A1

公开(公告)日：2007-08-16

申请号：US11613879

申请日：2006-12-20

申请人： Gordon Williams ,  John Funder ,  Susan Garthwaite ,  Barbara Roniker ,  Kenton Fedde ,  Ricardo Rocha

发明人： Gordon Williams ,  John Funder ,  Susan Garthwaite ,  Barbara Roniker ,  Kenton Fedde ,  Ricardo Rocha

IPC分类号： A61K31/58

CPC分类号： A61K45/06 ,  A61K31/00 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/437 ,  A61K31/5513 ,  A61K31/56 ,  A61K31/57 ,  A61K31/58 ,  A61K31/585 ,  A61K2300/00

摘要： The present invention provides methods for the treatment or prophylaxis of one or more aldosterone-mediated pathogenic effects in a subject suffering from or susceptible to the pathogenic effect or effects wherein the subject has one or more conditions selected from the group consisting of a sub-normal endogenous aldosterone level, salt sensitivity and an elevated dietary sodium intake. The methods comprise administering to the subject a therapeutically-effective amount of one or more epoxy-steroidal compounds that are aldosterone antagonists.

摘要翻译： 本发明提供了治疗或预防患有或易受致病作用或影响的受试者中一种或多种醛固酮介导的致病作用的方法，其中所述受试者具有一种或多种选自以下的病症：亚正常 内源性醛固酮水平，盐敏感性和膳食钠摄入量升高。 所述方法包括向受试者施用治疗有效量的一种或多种醛固酮拮抗剂的环氧甾族化合物。

公开(公告)号：US06410524B1

公开(公告)日：2002-06-25

申请号：US09434685

申请日：1999-11-05

申请人： Alfonzo T. Perez ,  Debra J. Asner ,  Richard J. LaChapelle ,  John C. Alexander ,  Barbara Roniker

发明人： Alfonzo T. Perez ,  Debra J. Asner ,  Richard J. LaChapelle ,  John C. Alexander ,  Barbara Roniker

IPC分类号： A61K31585

CPC分类号： A61K45/06 ,  A61K31/401 ,  A61K31/585 ,  A61K31/7048 ,  A61K38/05 ,  A61K38/556 ,  A61K2300/00

摘要： Combinations of an ACE inhibitor, an aldosterone antagonist, and a loop diuretic are described for use in treatment of circulatory disorders. Of particular interest are therapies using captopril, enalapril or lisinopril co-administered with spironolactone. This co-therapy would be particularly useful to reduce the death rate or the number of non-fatal hospitalizations or prevent the progression of congestive heart failure in patients with cardiovascular disease.

摘要翻译： 描述了ACE抑制剂，醛固酮拮抗剂和环利尿剂的组合用于治疗循环系统疾病。 特别令人感兴趣的是使用与安体舒通共同给药的卡托普利，依那普利或赖诺普利的疗法。 这种联合治疗对于降低死亡率或非致命性住院次数或预防心血管疾病患者充血性心力衰竭的进展将特别有用。

公开(公告)号：US5668134A

公开(公告)日：1997-09-16

申请号：US188296

申请日：1994-01-28

申请人： Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

发明人： Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

IPC分类号： A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505 ,  A61K31/65 ,  A61P31/04 ,  A61K31/395

CPC分类号： A61K31/65 ,  A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505

摘要： The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a photosensitivity and/or phototoxicity reaction in a patient comprising administering the prescribed or suggested dose of the medication to the patient during the evening or early morning hours.The present invention also provides an article of manufacture comprising: (1) a packaging material, and (2) a once-a-day dose medication which causes a photosensitivity and/or a phototoxicity reaction in a patient contained within said packaging material, wherein such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and wherein said packaging material comprises a label which indicates that such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and/or that such medication is to be administered during the evening or early morning hours, and/or wherein the packaging material is arranged in a manner which releases the medication to the patient during the evening or early morning hours.

摘要翻译： 本发明提供了一种用于预防或减少可能由每天一次的药物剂量引起的光敏性和/或光毒性反应的方法，其导致患者的光敏性和/或光毒性反应，包括施用规定的或建议的 晚上或清晨时间向病人服药。 本发明还提供了一种制品，其包括：（1）包装材料，和（2）在包含在所述包装材料内的患者中引起光敏性和/或光毒性反应的每天一次的剂量药物，其中 通过在傍晚或清晨时间向患者施用药物来防止或减少这种反应，并且其中所述包装材料包含通过在晚上向患者施用药物来防止或减少这种反应的标签 或清晨时间，和/或这种药物将在傍晚或清晨进行施用，和/或其中包装材料以在傍晚或清晨时间向患者释放药物的方式排列。

公开(公告)号：US20050250748A1

公开(公告)日：2005-11-10

申请号：US10637070

申请日：2003-08-06

申请人： John Alexander ,  Barbara Roniker ,  Subhash Desai

发明人： John Alexander ,  Barbara Roniker ,  Subhash Desai

IPC分类号： A61K31/401 ,  A61K31/56

CPC分类号： A61K31/401 ,  A61K31/56 ,  A61K45/06 ,  A61K2300/00

摘要： Combinations of an ACE inhibitor and an epoxy-steroidal aldosterone receptor antagonist are described for use in treatment of circulatory disorders. Of particular interest are therapies using epoxy-steroidal-type aldosterone receptor antagonist compounds, such as eplerenone, in combination with an angiotensin converting enzyme inhibitor. This co-therapy would be particularly useful to treat congestive heart failure while avoiding or reducing aldosterone-antagonist-induced side effects such as hyperkalemia.

摘要翻译： 描述了ACE抑制剂和环氧甾体醛固酮受体拮抗剂的组合用于治疗循环障碍。 特别令人感兴趣的是使用环氧甾体类醛固酮受体拮抗剂化合物如依普利酮与血管紧张素转换酶抑制剂组合的疗法。 治疗充血性心力衰竭同时避免或减少醛固酮拮抗剂诱导的副作用如高钾血症，这种联合治疗将特别有用。

公开(公告)号：US06172069B2

公开(公告)日：2001-01-09

申请号：US08936572

申请日：1997-09-24

申请人： Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

发明人： Paul Dale Klimstra ,  Barbara Roniker ,  Edward Allen Swabb

IPC分类号： A61K31395

CPC分类号： A61K31/65 ,  A61K31/00 ,  A61K31/495 ,  A61K31/496 ,  A61K31/505

摘要： The present invention provides a method for preventing or reducing a photosensitivity and/or phototoxicity reaction which may be caused by a once-per-day dose of a medication which causes a photosensitivity and/or phototoxicity reaction in a patient comprising administering the prescribed or suggested dose of the medication to the patient during the evening or early morning hours. The present invention also provides an article of manufacture comprising: (1) a packaging material, and (2) a once-a-day dose medication which causes a photosensitivity and/or a phototoxicity reaction in a patient contained within said packaging material, wherein such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and wherein said packaging material comprises a label which indicates that such a reaction is prevented or reduced by administering the medication to the patient during the evening or early morning hours, and/or that such medication is to be administered during the evening or early morning hours, and/or wherein the packaging material is arranged in a manner which releases the medication to the patient during the evening or early morning hours.

摘要翻译： 本发明提供了一种用于预防或减少可能由每天一次的药物剂量引起的光敏性和/或光毒性反应的方法，其导致患者的光敏性和/或光毒性反应，包括施用规定的或建议的 本发明还提供了一种制品，其包括：（1）包装材料，和（2）一天一次的剂量药物，其引起光敏性和 或者在所述包装材料中包含的患者中的光毒性反应，其中通过在傍晚或清晨时间向患者施用药物来防止或减少这种反应，并且其中所述包装材料包括标签，其指示这样的 通过在傍晚或清晨时间向患者施用药物来防止或减少反应，和/或这样的m 在傍晚或清晨时间期间施用鞣制，和/或其中包装材料以在傍晚或清晨时间向患者释放药物的方式排列。