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1.发明申请Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug 审中-公开制备抗微生物药物，对抗通常被认为对药物有抗性的生物有效公开(公告)号：US20050048126A1
公开(公告)日：2005-03-03
申请号：US10834541
申请日：2004-04-29
申请人： Barrett Rabinow , Randy White , Chong-Son Sun , Joseph Chung Wong , James Kipp , Mark Doty , Christine Rebbeck , Pavlos Papadopoulos
发明人： Barrett Rabinow , Randy White , Chong-Son Sun , Joseph Chung Wong , James Kipp , Mark Doty , Christine Rebbeck , Pavlos Papadopoulos
IPC分类号： A61K9/10 , A61K9/14 , A61K9/16 , A61K9/50 , A61K9/51 , A61K31/495 , A61K31/496 , A61K31/4196
CPC分类号： A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , A61K9/5015 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K31/495 , A61K31/496
摘要： The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 μm as measured by laser diffractometry.
摘要翻译： 本发明涉及抗微生物剂亚微米级微粒的组合物。 更具体地，本发明涉及一种抗微生物剂的组合物，其使得该试剂对通常被认为对该试剂具有抗性的生物有效。 该组合物包含亚微米级至微米级颗粒的含水悬浮液，其含有涂覆有选自以下的至少一种表面活性剂：离子表面活性剂，非离子表面活性剂，生物衍生的表面活性剂，以及氨基酸及其衍生物。 通过激光衍射测量，颗粒的体积加权平均粒度小于5um。
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2.发明授权Method for treating infectious organisms normally considered to be resistant to an antimicrobial drug 有权通常认为对抗微生物药物具有抗性的感染性生物体的治疗方法公开(公告)号：US08263131B2
公开(公告)日：2012-09-11
申请号：US12414484
申请日：2009-03-30
申请人： Barrett Rabinow , Randy White , Chong-Son Sun , Joseph Chung Take Wong , James E. Kipp , Mark Doty , Christine L. Rebbeck , Pavlos Papadopoulos
发明人： Barrett Rabinow , Randy White , Chong-Son Sun , Joseph Chung Take Wong , James E. Kipp , Mark Doty , Christine L. Rebbeck , Pavlos Papadopoulos
IPC分类号： A61K9/14
CPC分类号： A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1688 , A61K9/5015 , A61K9/5031 , A61K9/5036 , A61K9/5042 , A61K9/5123 , A61K9/5138 , A61K9/5146 , A61K9/5192 , A61K31/495 , A61K31/496
摘要： The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 μm as measured by laser diffractometry.
摘要翻译： 本发明涉及抗微生物剂亚微米级微粒的组合物。 更具体地，本发明涉及一种抗微生物剂的组合物，其使得该试剂对通常被认为对该试剂具有抗性的生物有效。 该组合物包含亚微米级至微米级颗粒的含水悬浮液，其含有涂覆有选自以下的至少一种表面活性剂：离子表面活性剂，非离子表面活性剂，生物衍生的表面活性剂，以及氨基酸及其衍生物。 通过激光衍射测量，颗粒具有小于5μm的体积加权平均粒度。
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公开(公告)号：US20060110462A1
公开(公告)日：2006-05-25
申请号：US11266518
申请日：2005-11-03
申请人： Pavlos Papadopoulos , Gerhard Raab , Mark Doty , James Kipp , Berthold Roessler
发明人： Pavlos Papadopoulos , Gerhard Raab , Mark Doty , James Kipp , Berthold Roessler
IPC分类号： A61K31/4439 , A61K9/14
CPC分类号： C07D401/12 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/5123 , A61K9/5146 , A61K31/404 , A61K31/4439 , Y10T428/2982
摘要： The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.
摘要翻译： 本发明涉及新的药物组合物，其包含吲哚化学类的水难溶性微管蛋白抑制剂的纳米微粒和微粒制剂，优选N-取代的吲哚-3-乙酰氧基酰胺，更优选N-（吡啶-4-基 ） - 也称为“靛敏蛋白”的[1-（4-氯苄基） - 吲哚-3-基]乙醛酸酰胺（D-24851），以及制备和使用这些组合物用于治疗抗肿瘤药物抗性的方法 癌症等疾病。
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公开(公告)号：US20150211153A1
公开(公告)日：2015-07-30
申请号：US14367746
申请日：2013-02-04
CPC分类号： B01D39/12 , B01D39/2041 , B01D2239/0654 , B01D2239/0672 , B01D2239/1216 , B01D2239/1225 , B01D2239/1233 , B01D2239/1291
摘要： A filter membrane has at its flow in side a first metal fibre web, at least two metal fibre layers, and a fine and at least one coarser fibre layer. The fine fibre layer is located at the flow in side of the filter membrane and the at least one coarser fibre layer is located downstream of the fine fibre layer. The filter membrane has at its flow out side, a stack of one or more first two-dimensional metal structures with constant and regular openings. The filter membrane also has at least one set formed by a second metal fibre web and a stack of one or more second two-dimensional metal structure with constant and regular openings; the at least one set is provided in between the stack of one or more two-dimensional metal structures that are having constant and regular openings, and the first metal fibre web.
摘要翻译： 过滤膜在其侧面流动有第一金属纤维网，至少两个金属纤维层，以及细的和至少一个较粗的纤维层。 细纤维层位于过滤膜的流动侧，并且至少一个较粗的纤维层位于细纤维层的下游。 过滤膜在其流出侧具有一个或多个具有恒定和规则开口的第一二维金属结构的堆叠。 过滤膜还具有由第二金属纤维网和具有恒定和规则开口的一个或多个第二二维金属结构的堆叠形成的至少一个集合; 至少一组设置在具有恒定和规则开口的一个或多个二维金属结构的堆叠之间以及第一金属纤维网之间。
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公开(公告)号：US20060062826A1
公开(公告)日：2006-03-23
申请号：US11273131
申请日：2005-11-14
IPC分类号： A61F2/00
CPC分类号： A61K9/0051
摘要： Disclosed is an improved sustained release drug delivery device and method of producing such device. The device comprises a drug core in an impermeable cup or impermeable coating layer that is adhered to an uncured suture tab and covered with a permeable polymer coating layer that is similar to the makeup of the suture tab. The permeable polymer coating layer that covers the device, covering the impermeable coating layer and at least a portion of the drug core, is cured (after drying) along with the uncured suture tab. The “cocuring” or one step curing process forms a very strong bond between the outer coating layer to the suture tab preventing leaks.
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公开(公告)号：US06756058B2
公开(公告)日：2004-06-29
申请号：US10035095
申请日：2001-12-27
IPC分类号： A61F900
CPC分类号： A61F9/0017 , A61K9/0051
摘要： The present invention is directed to an improved sustained release drug delivery device for delivering multiple agents comprising a drug core, a unitary cup, and a permeable plug.
摘要翻译： 本发明涉及一种改进的缓释药物递送装置，其用于递送包含药物核心，单一杯状物和可渗透塞子的多种药剂。
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公开(公告)号：US06756049B2
公开(公告)日：2004-06-29
申请号：US10023391
申请日：2001-12-17
申请人： Michael J. Brubaker , Ramesh Krishnamoorthy , Michael A. Lesczynski , Thomas F. Natalie , Pavlos Papadopoulos , Steven B. Renner , Santos Viscasillas , E. Allen Martin , Jason Paul Shropshire
发明人： Michael J. Brubaker , Ramesh Krishnamoorthy , Michael A. Lesczynski , Thomas F. Natalie , Pavlos Papadopoulos , Steven B. Renner , Santos Viscasillas , E. Allen Martin , Jason Paul Shropshire
IPC分类号： A61F200
CPC分类号： A61K9/0051 , A61K9/4808
摘要： The present invention is directed to an improved sustained release drug delivery device comprising a drug core, a unitary cup, and a permeable plug.
摘要翻译： 本发明涉及一种改进的缓释药物递送装置，其包括药物核心，整体杯和可渗透塞子。
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公开(公告)号：US06991808B2
公开(公告)日：2006-01-31
申请号：US10055584
申请日：2002-01-23
CPC分类号： A61K9/0051
摘要： Disclosed is an improved sustained release drug delivery device and method of producing such device. The device comprises a drug core in an impermeable cup or impermeable coating layer that is adhered to an uncured suture tab and covered with a permeable polymer coating layer that is similar to the makeup of the suture tab. The permeable polymer coating layer that covers the device, covering the impermeable coating layer and at least a portion of the drug core, is cured (after drying) along with the uncured suture tab. The “cocuring” or one step curing process forms a very strong bond between the outer coating layer to the suture tab preventing leaks.
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