公开(公告)号：US07230143B2

公开(公告)日：2007-06-12

申请号：US11029197

申请日：2005-01-04

申请人： Barry Jones ,  Ashot Khrimian ,  Joel Swinson ,  Paul Cross

发明人： Barry Jones ,  Ashot Khrimian ,  Joel Swinson ,  Paul Cross

IPC分类号： C07C41/34

CPC分类号： C07C41/38 ,  B01J20/285 ,  B01J2220/54 ,  C07C41/01 ,  C07C41/42 ,  G01N2030/025 ,  G01N2030/884 ,  G01N2030/8845 ,  C07C43/123

摘要： A method in which organic matter found in a crude sevoflurane may be separated, identified, and quantified using a CARBOWAX™ (polyethylene glycol) capillary gas chromatographic column or an alkyl polysiloxane capillary gas chromatographic column. Also provided is a process control method for the production of sevoflurane, wherein the content of a particular component in one of the following steps is determined, and in that, assuming this as a variable, the treatment condition of the step is adjusted: 1) a step of extracting, or cooling to form two layers, and/or distilling a mixture of crude sevoflurane and hydrogen fluoride (HF) in order to isolate the majority of the sevoflurane and 2) an optional step of purifying the crude sevoflurane and 3) a step of distilling crude sevoflurane. Also provided is a method for determining the impurity level of a purified sevoflurane that is acceptable for use in human/animal anesthesia.

摘要翻译： 可以使用CARBOWAX TM（聚乙二醇）毛细管气相色谱柱或烷基聚硅氧烷毛细管气相色谱柱分离，鉴定和定量在七氟烷粗品中发现的有机物质的方法。 还提供了用于生产七氟醚的过程控制方法，其中确定以下步骤之一中的特定组分的含量，并且其中将其作为变量，将步骤的处理条件调整为：1） 提取或冷却形成两层和/或蒸馏粗七氟烷和氟化氢（HF）的混合物以分离大部分七氟醚的步骤，和2）任选的纯化七氟烷的步骤，和3） 蒸馏粗品七氟烷的步骤。 还提供了一种用于确定在人/动物麻醉中可以使用的纯化七氟醚的杂质水平的方法。

公开(公告)号：US20050234268A1

公开(公告)日：2005-10-20

申请号：US11029197

申请日：2005-01-04

申请人： Barry Jones ,  Ashot Khrimian ,  Joel Swinson ,  Paul Cross

发明人： Barry Jones ,  Ashot Khrimian ,  Joel Swinson ,  Paul Cross

IPC分类号： B01J20/285 ,  C07C41/01 ,  C07C41/16 ,  C07C41/42 ,  C07C43/12 ,  G01N30/02 ,  G01N30/88

CPC分类号： C07C41/38 ,  B01J20/285 ,  B01J2220/54 ,  C07C41/01 ,  C07C41/42 ,  G01N2030/025 ,  G01N2030/884 ,  G01N2030/8845 ,  C07C43/123

摘要： A method in which organic matter found in a crude sevoflurane may be separated, identified, and quantified using a CARBOWAX™ (polyethylene glycol) capillary gas chromatographic column or an alkyl polysiloxane capillary gas chromatographic column. Also provided is a process control method for the production of sevoflurane, wherein the content of a particular component in one of the following steps is determined, and in that, assuming this as a variable, the treatment condition of the step is adjusted: 1) a step of extracting, or cooling to form two layers, and/or distilling a mixture of crude sevoflurane and hydrogen fluoride (HF) in order to isolate the majority of the sevoflurane and 2) an optional step of purifying the crude sevoflurane and 3) a step of distilling crude sevoflurane. Also provided is a method for determining the impurity level of a purified sevoflurane that is acceptable for use in human/animal anesthesia.

摘要翻译： 可以使用CARBOWAX TM（聚乙二醇）毛细管气相色谱柱或烷基聚硅氧烷毛细管气相色谱柱分离，鉴定和定量在七氟烷粗品中发现的有机物质的方法。 还提供了用于生产七氟醚的过程控制方法，其中确定以下步骤之一中的特定组分的含量，并且其中将其作为变量，将步骤的处理条件调整为：1） 提取或冷却形成两层和/或蒸馏粗七氟烷和氟化氢（HF）的混合物以分离大部分七氟醚的步骤，和2）任选的纯化七氟烷的步骤，和3） 蒸馏粗品七氟烷的步骤。 还提供了一种用于确定在人/动物麻醉中可以使用的纯化七氟醚的杂质水平的方法。

公开(公告)号：US09150480B2

公开(公告)日：2015-10-06

申请号：US11813785

申请日：2006-01-06

申请人： Joel Swinson ,  Barry Jones ,  Danny Graham ,  Neville Pavri

发明人： Joel Swinson ,  Barry Jones ,  Danny Graham ,  Neville Pavri

IPC分类号： C07C41/22 ,  C07C43/12

CPC分类号： C07C43/123 ,  C07C41/22

摘要： A process for preparing fluorinated ethers, such as desflurane, comprises reacting the corresponding chlorinated ether, such as isoflurane, with anhydrous hydrogen fluoride in the vapor phase in the presence of chromia catalyst. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 制备氟代醚的方法，如地氟烷，包括在铬酸催化剂存在下，使气相中的相应的氯化醚如异氟烷与无水氟化氢反应。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。

公开(公告)号：US07732647B2

公开(公告)日：2010-06-08

申请号：US11965137

申请日：2007-12-27

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/38

CPC分类号： C07C41/01 ,  C07C41/38 ,  Y02P20/127 ,  C07C43/123

摘要： A process for purifying crude fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane). The crude sevoflurane is repeatedly washed with water under conditions and for a time sufficient to reduce the level of 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) to no more than 200 ppm or no more than 100 ppm.

摘要翻译： 粗氟甲基1,1,1,3,3,3-六氟异丙醚（七氟醚）的纯化方法。 在足以将1,1,1,3,3,3-六氟异丙醇（HFIP）的水平降低至不大于200ppm或不超过100ppm的条件下，用水重复洗涤粗制七氟醚。

公开(公告)号：US20090275785A1

公开(公告)日：2009-11-05

申请号：US12113655

申请日：2008-05-01

申请人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

发明人： Barry Jones ,  Joel Swinson ,  Paul Mazzell

IPC分类号： C07C41/42 ,  B08B3/08

CPC分类号： C07C41/42 ,  C07C43/123

摘要： Processes for preparing commercial quantities of a stable, pharmaceutically acceptable sevoflurane substantially tree of impurities are claimed. In another embodiment, a process for removing reactive metal, salts from the surface of metallic equipment used in the distillation of sevoflurane and rendering a non-inert metallic surface of the metallic equipment inert.

摘要翻译： 要求用于制备商业量的稳定的药学上可接受的七氟烷基本上杂质树的方法。 在另一个实施方案中，从用于蒸馏七氟醚的金属设备的表面除去活性金属盐，并使金属设备的非惰性金属表面呈惰性的方法。

公开(公告)号：US20080214875A1

公开(公告)日：2008-09-04

申请号：US11997435

申请日：2006-08-02

申请人： Barry Jones ,  Joel Swinson

发明人： Barry Jones ,  Joel Swinson

IPC分类号： C07C41/34

CPC分类号： C07C41/42 ,  C07C43/123

摘要： Crude sevoflurane product comprising unacceptably high levels of HFIP can be purified by combining the crude sevoflurane product with sufficient water to produce a multiphase mixture, fractionally distilling the multiphase mixture, and removing substantially pure sevoflurane from the distilling multiphase mixture. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 包含不可接受的高水平HFIP的粗七氟烷产物可以通过将粗七氟烷产物与足够的水结合以产生多相混合物，分馏蒸馏多相混合物，以及从蒸馏多相混合物中除去基本上纯的七氟醚，来纯化。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。

公开(公告)号：US20080058560A1

公开(公告)日：2008-03-06

申请号：US10599472

申请日：2005-02-04

申请人： Paul Massell ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

发明人： Paul Massell ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

IPC分类号： C07C29/132 ,  C07C29/74

CPC分类号： C07C29/145 ,  C07C29/76 ,  C07C29/80 ,  C07C31/38

摘要： 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) substantially free of 1,1,1-trifluoroacetone (TFA) can be separated from a mixture containing both compounds by A) catalytic reduction with hydrogen followed by fractional distillation; B) cooling to a temperature at which HFIP freezes and TFA remains liquid; C) forming a high boiling complex comprising HF and TFA followed by fractional distillation; or D) producing HF-free conditions to yield a HFIP/TFA azeotrope followed by fractional distillation. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR § 1.72(b).

摘要翻译： 基本上不含1,1,1-三氟丙酮（TFA）的1,1,1,3,3,3-六氟异丙醇（HFIP）可以从含有这两种化合物的混合物中分离出来，A）用氢气催化还原，然后分馏; B）冷却至HFIP冻结的温度，TFA保持液态; C）形成包含HF和TFA的高沸点络合物，然后分馏; 或D）产生无HF条件以产生HFIP / TFA共沸物，随后进行分馏。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR§1.72（b）。

公开(公告)号：US07659433B2

公开(公告)日：2010-02-09

申请号：US10599472

申请日：2005-02-04

申请人： Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

发明人： Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

IPC分类号： C07C29/145 ,  C07C29/82 ,  C07C29/80

CPC分类号： C07C29/145 ,  C07C29/76 ,  C07C29/80 ,  C07C31/38

摘要： 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) substantially free of 1,1,1-trifluoroacetone (TFA) can be separated from a mixture containing both compounds by A) catalytic reduction with hydrogen followed by fractional distillation; B) cooling to a temperature at which HFIP freezes and TFA remains liquid; C) forming a high boiling complex comprising HF and TFA followed by fractional distillation; or D) producing HF-free conditions to yield a HFIP/TFA azeotrope followed by fractional distillation. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR § 1.72(b).

摘要翻译： 基本上不含1,1,1-三氟丙酮（TFA）的1,1,1,3,3,3-六氟异丙醇（HFIP）可以从含有这两种化合物的混合物中分离出来，A）用氢气催化还原，然后分馏; B）冷却至HFIP冻结的温度，TFA保持液态; C）形成包含HF和TFA的高沸点络合物，然后分馏; 或D）产生无HF条件以产生HFIP / TFA共沸物，随后进行分馏。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR§1.72（b）。

公开(公告)号：US20080306309A1

公开(公告)日：2008-12-11

申请号：US11815673

申请日：2006-02-09

申请人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

发明人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

IPC分类号： C07C41/42 ,  C09K3/00

CPC分类号： C07C41/40 ,  C07C41/38 ,  C07C41/42 ,  C07C43/123

摘要： An azeotrope comprising desflurane (CF3CFHOCF2H) and hydrogen fluoride (HF). The azeotrope can be prepared by fractionally distilling a crude mixture of desflurane and HF. Purer desflurane can be readily and easily separated from the azeotrope. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 包含地氟烷（CF 3 CFHOCF 2 H）和氟化氢（HF）的共沸物。 可以通过分馏蒸馏地氟烷和HF的粗混合物来制备共沸物。 Purer地氟烷可以容易地和容易地从共沸物中分离出来。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。

公开(公告)号：US08283500B2

公开(公告)日：2012-10-09

申请号：US11815673

申请日：2006-02-09

申请人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

发明人： Paul Mazzell ,  Barry Jones ,  Neville Pavri ,  Joel Swinson

IPC分类号： C07C43/00

CPC分类号： C07C41/40 ,  C07C41/38 ,  C07C41/42 ,  C07C43/123

摘要： An azeotrope comprising desflurane (CF3CFHOCF2H) and hydrogen fluoride (HF). The azeotrope can be prepared by fractionally distilling a crude mixture of desflurane and HF. Purer desflurane can be readily and easily separated from the azeotrope. It is emphasized that this abstract is provided to comply with the rules requiring an abstract which will allow a searcher or other reader quickly to ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the appended issued claims.

摘要翻译： 包含地氟烷（CF 3 CFHOCF 2 H）和氟化氢（HF）的共沸物。 可以通过分馏蒸馏地氟烷和HF的粗混合物来制备共沸物。 Purer地氟烷可以容易地和容易地从共沸物中分离出来。 要强调的是，该摘要被提供以符合要求抽象的规则，这将允许搜索者或其他读者快速地确定技术公开的主题。 提交它的理解是，它不会用于解释或限制所附权利要求的范围或含义。