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公开(公告)号：US20140221348A1
公开(公告)日：2014-08-07
申请号：US14216486
申请日：2014-03-17
IPC分类号： C07D519/00 , C07D471/04 , C07D513/04 , C07D498/04 , C07D405/14 , C07D417/14 , C07D413/14
CPC分类号： C07D513/04 , C07D215/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The antibacterial compound of formula I wherein X1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6 represents a nitrogen atom; X2 represents C—H, C—(C1-C6alkyl), C—(C1-C6alkoxy), C-halogen, C—COOH; X5 represents C—H or C—(C1-C6alkyl), C-halogen; A1, A2, A3, R1 and R4 represent various substituents, G represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.
摘要翻译： 式I的抗菌化合物，其中X 1，X 3; X 4和X 6各自独立地表示氮原子或CR 2，条件是X 1，X 3; X4和X6表示氮原子; X代表C-H，C-（C 1 -C 6烷基），C-（C 1 -C 6烷氧基），C-卤素，C-COOH; X 5表示C-H或C-（C 1 -C 6烷基），C-卤素; A1，A2，A3，R1和R4表示各种取代基，G表示未取代或取代的芳基或杂芳基，哪种化合物对病原菌表现出良好的活性。
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公开(公告)号：US20150080373A1
公开(公告)日：2015-03-19
申请号：US14552853
申请日：2014-11-25
IPC分类号： C07D513/04 , C07D498/04 , C07D413/14 , C07D215/20 , C07D405/14 , C07D409/12 , C07D401/12 , C07D495/04 , C07D417/14 , C07D413/12
CPC分类号： C07D513/04 , C07D215/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The antibacterial compound of formula I wherein X1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6 represents a nitrogen atom; X2 represents C—H, C—(C1-C6alkyl), C—(C1-C6alkoxy), C-halogen, C—COOH; X5 represents C—H or C—(C1-C6alkyl), C-halogen; A1, A2, A3, R1 and R4 represent various substituents, G represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.
摘要翻译： 式I的抗菌化合物，其中X 1，X 3; X 4和X 6各自独立地表示氮原子或CR 2，条件是X 1，X 3; X4和X6表示氮原子; X代表C-H，C-（C 1 -C 6烷基），C-（C 1 -C 6烷氧基），C-卤素，C-COOH; X 5表示C-H或C-（C 1 -C 6烷基），C-卤素; A1，A2，A3，R1和R4表示各种取代基，G表示未取代或取代的芳基或杂芳基，哪种化合物对病原菌表现出良好的活性。
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3.发明申请USEFUL COMBINATIONS OF MONOBACTAM ANTIBIOTICS WITH BETA-LACTAMASE INHIBITORS 有权单克隆抗体与BETA-LACTAMASE抑制剂的有用组合公开(公告)号：US20150031662A1
公开(公告)日：2015-01-29
申请号：US14512847
申请日：2014-10-13
IPC分类号： C07D417/14 , A61K31/4439 , C07D417/12 , A61K31/427 , C07D401/14 , C07D413/14 , A61K31/444 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4725 , A61K31/41 , A61K31/433 , A61K31/407 , A61K31/496 , C07D487/04
CPC分类号： C07D417/14 , A61K31/407 , A61K31/41 , A61K31/427 , A61K31/43 , A61K31/433 , A61K31/4375 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/545 , A61K31/662 , A61K31/69 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , Y02A50/473
摘要： A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
摘要翻译： 包含式（I）的抗生素活性化合物与式（II）至（XIII）之一的β-内酰胺酶抑制剂的组合的药物组合物对革兰氏阴性细菌特别是这种细菌具有活性 其已经变得抵抗抗生素如氨曲南，卡努康和蒂格胺。 任选地，组合物可以包含式（II）至（XIII）之一，特别是式（V）或式（VI）之一的另一种β-内酰胺酶抑制剂。
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4.发明授权Useful combinations of monobactam antibiotics with beta-lactamase inhibitors 有权单链内酰胺抗生素与β-内酰胺酶抑制剂的有用组合公开(公告)号：US09346799B2
公开(公告)日：2016-05-24
申请号：US14512847
申请日：2014-10-13
IPC分类号： A61K31/4439 , C07D417/14 , C07D487/04 , C07D417/12 , A61K31/427 , C07D417/04 , A61K31/407 , A61K31/43 , A61K31/4436 , A61K31/545 , A61K31/662 , A61K31/69 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D471/04 , A61K31/41 , A61K31/433 , A61K31/4375 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506
CPC分类号： C07D417/14 , A61K31/407 , A61K31/41 , A61K31/427 , A61K31/43 , A61K31/433 , A61K31/4375 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/545 , A61K31/662 , A61K31/69 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , Y02A50/473
摘要： A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
摘要翻译： 包含式（I）的抗生素活性化合物与式（II）至（XIII）之一的β-内酰胺酶抑制剂的组合的药物组合物对革兰氏阴性细菌特别是这种细菌具有活性 其已经变得抵抗抗生素如氨曲南，卡努康和蒂格胺。 任选地，组合物可以包含式（II）至（XIII）之一，特别是式（V）或式（VI）之一的另一种β-内酰胺酶抑制剂。
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公开(公告)号：US20160122320A1
公开(公告)日：2016-05-05
申请号：US14993747
申请日：2016-01-12
IPC分类号： C07D401/14
CPC分类号： C07D417/14 , A61K31/407 , A61K31/41 , A61K31/427 , A61K31/43 , A61K31/433 , A61K31/4375 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/545 , A61K31/662 , A61K31/69 , A61K45/06 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , Y02A50/473
摘要： A pharmaceutical composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active against Gram-negative bacteria, in particular such bacteria which have become resistant against antibiotics such as aztreonam, carumonam and tigemonam. Optionally the compositions may comprise another β-lactamase inhibitor of one of the formulae (II) to (XIII), particularly of formula (V) or formula (VI).
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公开(公告)号：US09133219B2
公开(公告)日：2015-09-15
申请号：US14552853
申请日：2014-11-25
IPC分类号： C07D513/04 , C07D417/14 , C07D498/04 , C07D413/14 , C07D413/12 , C07D405/14 , C07D409/12 , C07D495/04 , C07D215/20 , C07D405/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D519/00 , C07D401/12
CPC分类号： C07D513/04 , C07D215/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The antibacterial compound of formula I wherein X1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6 represents a nitrogen atom; X2 represents C—H, C—(C1-C6alkyl), C—(C1-C6alkoxy), C-halogen, C—COOH; X5 represents C—H or C—(C1-C6alkyl), C-halogen; A1, A2, A3, R1 and R4 represent various substituents, G represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.
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公开(公告)号：US08927542B2
公开(公告)日：2015-01-06
申请号：US14216486
申请日：2014-03-17
IPC分类号： C07D498/04 , A61K31/536 , A61K31/5365
CPC分类号： C07D513/04 , C07D215/20 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要： The antibacterial compound of formula I wherein X1, X3; X4 and X6, each independently of the others, represents a nitrogen atom or CR2, with the proviso that at least one of X1, X3; X4 and X6 represents a nitrogen atom; X2 represents C—H, C—(C1-C6alkyl), C—(C1-C6alkoxy), C-halogen, C—COOH; X5 represents C—H or C—(C1-C6alkyl), C-halogen; A1, A2, A3, R1 and R4 represent various substituents, G represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.
摘要翻译： 式I的抗菌化合物，其中X 1，X 3; X 4和X 6各自独立地表示氮原子或CR 2，条件是X 1，X 3; X4和X6表示氮原子; X代表C-H，C-（C 1 -C 6烷基），C-（C 1 -C 6烷氧基），C-卤素，C-COOH; X 5表示C-H或C-（C 1 -C 6烷基），C-卤素; A1，A2，A3，R1和R4表示各种取代基，G表示未取代或取代的芳基或杂芳基，哪种化合物对病原菌表现出良好的活性。
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