公开(公告)号：US20150151141A1

公开(公告)日：2015-06-04

申请号：US14406125

申请日：2013-06-04

申请人： Bastien Arnal ,  Mathieu Pernot ,  Mickaël Tanter ,  Mathias Fink

发明人： Bastien Arnal ,  Mathieu Pernot ,  Mickaël Tanter ,  Mathias Fink

IPC分类号： A61N7/00 ,  G10K15/00

摘要： Device for focusing pulses comprising at least emitting means comprising a network of transducers, these emitting means being adapted to make the network of transducers emit, into a reflective cavity, at least one wave focused onto at least one target point of a target medium. The reflective cavity comprises a multi-scattering medium adapted to cause multiple scattering of said wave.

摘要翻译： 用于聚焦脉冲的装置至少包括包括换能器网络的发射装置，这些发射装置适于使得换能器网络发射到反射腔中，聚焦在目标介质的至少一个目标点上的至少一个波。 反射腔包括适于引起所述波的多次散射的多散射介质。

公开(公告)号：US09168021B2

公开(公告)日：2015-10-27

申请号：US12478514

申请日：2009-06-04

申请人： Mathieu Pernot ,  Mickaël Tanter ,  Mathieu Couade ,  Mathias Fink

发明人： Mathieu Pernot ,  Mickaël Tanter ,  Mathieu Couade ,  Mathias Fink

IPC分类号： A61B8/00 ,  A61B8/08 ,  G01N29/11 ,  G01S7/52

CPC分类号： A61B8/08 ,  A61B8/0883 ,  A61B8/485 ,  G01N29/11 ,  G01N2291/02827 ,  G01N2291/0422 ,  G01N2291/044 ,  G01S7/52036 ,  G01S7/52042

摘要： A Method for measuring heart contractility of a patient, in which a mechanical shear wave is propagated through the heart and observation of the propagation leads to determine a shear wave propagation parameter representative of the elasticity of the heart is disclosed. The value of the propagation parameter at the end of a systole is sampled, which leads to a parameter representative of the end systolic elastance.

摘要翻译： 公开了一种用于测量患者的心脏收缩力的方法，其中机械剪切波通过心脏传播并观察传播，导致确定代表心脏弹性的剪切波传播参数。 收缩收缩末期的传播参数的值被采样，这导致代表收缩末期弹性的参数。

公开(公告)号：US08155725B2

公开(公告)日：2012-04-10

申请号：US12282625

申请日：2008-02-20

申请人： Mathieu Pernot ,  Mathias Fink ,  Mickaël Tanter ,  Gabriel Montaldo ,  Jean-Francois Aubry ,  Ralph Sinkus

发明人： Mathieu Pernot ,  Mathias Fink ,  Mickaël Tanter ,  Gabriel Montaldo ,  Jean-Francois Aubry ,  Ralph Sinkus

IPC分类号： A61B5/05

CPC分类号： G01S7/52049 ,  A61B8/0808 ,  A61N7/02 ,  A61N2007/0078 ,  A61N2007/0095 ,  G01S15/8909

摘要： The invention concerns a method for optimizing the focusing of waves in a zone of interest of a medium, with the waves being emitted by a network of sources to the medium through an aberration-inducing element that introduces an initially indeterminate phase shift. The method according to the invention proposes to use M−1 successive modifications of the emitted wave, each giving rise to a perturbation. According to the invention, the M perturbations are measured in the zone of interest at each modification of the phase and/or amplitude distributions, and these measurements are used to deduce optimal focusing characteristics to maximize the perturbation induced in the zone of interest.

摘要翻译： 本发明涉及一种用于优化介质感兴趣区域中的波的聚焦的方法，其中波被源网络通过引入初始不确定相移的像差诱导元件发射到介质。 根据本发明的方法提出使用发射波的M-1个连续修改，每个引起扰动。 根据本发明，在相位和/或幅度分布的每个修改时，在感兴趣的区域中测量M扰动，并且这些测量用于推导最佳聚焦特性，以使感兴趣区域中诱导的扰动最大化。

公开(公告)号：US20100312116A1

公开(公告)日：2010-12-09

申请号：US12478514

申请日：2009-06-04

申请人： Mathieu Pernot ,  Mickaël Tanter ,  Mathieu Couade ,  Mathias Fink

发明人： Mathieu Pernot ,  Mickaël Tanter ,  Mathieu Couade ,  Mathias Fink

IPC分类号： A61B8/00

CPC分类号： A61B8/08 ,  A61B8/0883 ,  A61B8/485 ,  G01N29/11 ,  G01N2291/02827 ,  G01N2291/0422 ,  G01N2291/044 ,  G01S7/52036 ,  G01S7/52042

摘要： A Method for measuring heart contractility of a patient, in which a mechanical shear wave is propagated through the heart and observation of the propagation leads to determine a shear wave propagation parameter representative of the elasticity of the heart is disclosed. The value of the propagation parameter at the end of a systole is sampled, which leads to a parameter representative of the end systolic elastance.

摘要翻译： 公开了一种用于测量患者的心脏收缩力的方法，其中机械剪切波通过心脏传播并观察传播，导致确定代表心脏弹性的剪切波传播参数。 收缩收缩末期的传播参数的值被采样，这导致代表收缩末期弹性的参数。

公开(公告)号：US08545407B2

公开(公告)日：2013-10-01

申请号：US12599260

申请日：2007-05-16

申请人： Jeremy Bercoff ,  David Savery ,  Mickaël Tanter ,  Jean-Luc Gennisson ,  Mathias Fink ,  Claude Cohen-Bacrie

发明人： Jeremy Bercoff ,  David Savery ,  Mickaël Tanter ,  Jean-Luc Gennisson ,  Mathias Fink ,  Claude Cohen-Bacrie

IPC分类号： A61B8/00

CPC分类号： A61B8/485 ,  A61B5/0051 ,  A61B8/08 ,  A61B8/4483 ,  G01S7/52036 ,  G01S7/52042 ,  G01S15/8927

摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. The method uses a single probe carrying at least one transducer and includes the steps of: (a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from the constraint zone into the tissue, (b1) measuring, with the transducer, the transient tissue displacements in at least one first measurement zone in the tissue, and wherein the first measurement zone is located away from the constraint zone, and (c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from the measured transient tissue displacements of the tissue in the first measurement zone.

摘要翻译： 本发明涉及一种用于测量软材料的平均粘弹性值的方法。 该方法使用携带至少一个换能器的单个探针，并且包括以下步骤：（a）在约束区域中诱导至少一个机械振动的爆发，以便在从约束区域传播的组织中产生内部剪切波， （b1）用传感器测量组织中至少一个第一测量区域中的瞬时组织位移，并且其中第一测量区域远离约束区域，以及（c）估计平均粘度 - 位于约束区域和第一测量区域之间的组织区域的弹性，来自第一测量区域中组织的测量的瞬时组织位移。

公开(公告)号：US09952321B2

公开(公告)日：2018-04-24

申请号：US11910491

申请日：2006-03-30

申请人： Mathias Fink ,  Ralph Sinkus ,  Mickaël Tanter ,  Jeremy Bercoff

发明人： Mathias Fink ,  Ralph Sinkus ,  Mickaël Tanter ,  Jeremy Bercoff

IPC分类号： G01S15/89 ,  A61B8/08 ,  A61B8/00 ,  G01S7/52 ,  A61B5/00

CPC分类号： G01S15/8909 ,  A61B5/0051 ,  A61B8/0825 ,  A61B8/406 ,  A61B8/42 ,  A61B8/485 ,  G01S7/52026 ,  G06F19/00

摘要： The inventive imaging method consists in generating a mechanical wave having shearing and compressional components in a viscoelastic medium and in determining the movement parameter of said viscoelastic medium at different points during the propagation of said mechanical wave. Said method comprises a correction stage when the movement parameter is processed for eliminating errors caused by the compressional component of the mechanical wave.

公开(公告)号：US07857762B2

公开(公告)日：2010-12-28

申请号：US10517047

申请日：2003-05-28

申请人： Gabriel Montaldo ,  Mathias Fink ,  Mickaël Tanter

发明人： Gabriel Montaldo ,  Mathias Fink ,  Mickaël Tanter

IPC分类号： A61B8/00 ,  A61H1/00 ,  G01N9/24

CPC分类号： G01S7/52049 ,  A61B8/15 ,  G10K11/34

摘要： The invention relates to a method of generating a predetermined objective wave field in a medium using a first network of transducers T1-Tn). The inventive method consists in first using each transducer i of the first network to emit an approximation of the signal ei(t). Subsequently, each transducer of a second network of transducers (T′1-T′m) is used to emit an error signal corresponding to the time reversal of the difference between the signals captured from said first emission and objective signals. Finally, approximation ei(t) is corrected by subtracting the time reversal of the signal captured by each transducer i using the error signal.

摘要翻译： 本发明涉及使用第一传感器网络T1-Tn）在介质中产生预定目标波场的方法。 本发明的方法包括首先使用第一网络的每个换能器i发射信号ei（t）的近似。 随后，第二传感器网络（T'1-T'm）的每个换能器用于发射对应于从所述第一发射和目标信号捕获的信号之间的差的时间反转的误差信号。 最后，通过使用误差信号减去由每个换能器i捕获的信号的时间反转来校正近似值ei（t）。

公开(公告)号：US20100222678A1

公开(公告)日：2010-09-02

申请号：US12599260

申请日：2007-05-16

申请人： Jeremy Bercoff ,  David Savery ,  Mickaël Tanter ,  Jean-Luc Gennisson ,  Mathias Fink ,  Claude Cohen-Bacrie

发明人： Jeremy Bercoff ,  David Savery ,  Mickaël Tanter ,  Jean-Luc Gennisson ,  Mathias Fink ,  Claude Cohen-Bacrie

IPC分类号： A61B8/00

CPC分类号： A61B8/485 ,  A61B5/0051 ,  A61B8/08 ,  A61B8/4483 ,  G01S7/52036 ,  G01S7/52042 ,  G01S15/8927

摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of: a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue, b1) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone, c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.

摘要翻译： 本发明涉及一种用于测量软材料的平均粘弹性值的方法。 使用携带至少一个换能器的单个探针的所述方法包括以下步骤：a）在约束区域中诱导至少一个机械振动爆发，以便在从所述约束区传播到组织中的组织中产生内部剪切波 ，b1）用所述换能器测量组织中的至少一个第一测量区域中的瞬时组织位移，所述第一测量区域位于远离所述约束区域，c）估计组织区域的平均粘弹性 位于所述约束区域和所述第一测量区域之间，所述第一测量区域中的所述组织的测量的瞬时组织位移。

公开(公告)号：US07837623B2

公开(公告)日：2010-11-23

申请号：US10526561

申请日：2003-08-20

申请人： Jean-François Aubry ,  Mathias Fink ,  Mickaël Tanter

发明人： Jean-François Aubry ,  Mathias Fink ,  Mickaël Tanter

IPC分类号： A61B8/00

CPC分类号： A61B8/0816 ,  A61B5/107 ,  A61B5/7257 ,  A61B8/00 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/4455 ,  A61N7/02 ,  G01S7/52049

摘要： A non-invasive method of obtaining a target soundwave field in the brain by means of an array of transducers positioned outside the skull, the method comprising a training stage during which, on the basis of a three-dimensional image giving the porosity of the skull at all points, digital simulation is used to determine individual sound signals to be emitted by the transducers in order to obtain the target soundwave field in the brain. After the training stage, the array of transducers is used to locate the position of the array of transducers relative to the skull by echography and to ensure that the array of transducers is accurately positioned.

摘要翻译： 一种通过位于颅骨外部的换能器阵列获得大脑中的目标声波场的非侵入性方法，该方法包括训练阶段，在该训练阶段期间，基于提供颅骨孔隙度的三维图像 在所有点上，数字模拟用于确定由换能器发射的各个声音信号，以便获得大脑中的目标声波场。 在训练阶段之后，传感器阵列用于通过回波测量来定位传感器阵列相对于颅骨的位置，并确保换能器阵列被精确定位。

公开(公告)号：US20100170342A1

公开(公告)日：2010-07-08

申请号：US12666240

申请日：2008-06-23

申请人： Ralph Sinkus ,  Mickaël Tanter ,  Matthias Fink ,  Jeremy Bercoff ,  David Savery

发明人： Ralph Sinkus ,  Mickaël Tanter ,  Matthias Fink ,  Jeremy Bercoff ,  David Savery

IPC分类号： G01N29/024 ,  G01N29/032

CPC分类号： G01N29/032 ,  A61B8/08 ,  A61B8/485 ,  G01N29/024 ,  G01N29/06 ,  G01N29/07 ,  G01N29/11 ,  G01N2203/0094 ,  G01N2291/02475 ,  G01N2291/02483 ,  G01N2291/02491 ,  G01N2291/02827 ,  G01S7/52038 ,  G01S15/8906

摘要： Method for rheological characterization of a viscoelastic medium, comprising the following steps: (a) an excitation step during which a vibratory excitation is generated in the viscoelastic medium leading to a deformation of the medium, (b) a deformation measurement step during which the deformation of the medium caused by the excitation is observed, (c) and a characterization step during which at least one non-zero power parameter y is determined such that a rheological parameter of the medium x is equal to x (f)=a+b.fy, where f is the frequency, a is a real number and b a non-zero scale parameter. It is thus possible to obtain mapping of the power parameter y.

摘要翻译： 粘弹性介质的流变学表征方法，包括以下步骤：（a）在粘弹性介质中产生振动激发导致介质变形的激发步骤，（b）变形测量步骤， 观察到由激励引起的介质的（c）和表征步骤，其中确定至少一个非零功率参数y，使得介质x的流变参数等于x（f）= a + b .fy，其中f是频率，a是实数和ba非零比例参数。 因此，可以获得功率参数y的映射。