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公开(公告)号：US11492189B2
公开(公告)日：2022-11-08
申请号：US16774190
申请日：2020-01-28
发明人： Analuz Mark , Ivan M. Nuñez , Vicki L. Barniak , Jennifer M. Hunt , Lynn Coullard , Keyla M. Cubi
IPC分类号： C11D9/36 , B65D81/22 , A45C11/00 , C07D263/34 , C08F283/12 , C08F290/06 , C11D3/00 , C11D3/48
摘要： A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more hydrophilic polymers or copolymers comprising hydrophilic units and endcapped with a hydrophobic end group and a hydrophilic end group, wherein the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.
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公开(公告)号：US10668676B2
公开(公告)日：2020-06-02
申请号：US16100732
申请日：2018-08-10
发明人： Ivan M. Nuñez , Lynn Coullard , Daniel J. Hook , Robert B. Steffen , Daniel M. Ammon , Jennifer M. Hunt , Analuz Mark
IPC分类号： G02B1/04 , B29D11/00 , C08F293/00 , C08L33/12 , B29K105/00 , C08F22/28 , C08F20/12 , C08F22/26 , C08F20/14 , B29K33/00 , C08F22/10
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.
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公开(公告)号：US20200239217A1
公开(公告)日：2020-07-30
申请号：US16774190
申请日：2020-01-28
发明人： Analuz Mark , Ivan M. Nuñez , Vicki L. Barniak , Jennifer M. Hunt , Lynn Coullard , Keyla M. Cubi
IPC分类号： B65D81/22 , A45C11/00 , C08F283/12 , C07D263/34 , C08F290/06
摘要： A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising one or more hydrophilic polymers or copolymers comprising hydrophilic units and endcapped with a hydrophobic end group and a hydrophilic end group, wherein the solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.
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公开(公告)号：US20200047437A1
公开(公告)日：2020-02-13
申请号：US16100732
申请日：2018-08-10
发明人： Ivan M. Nuñez , Lynn Coullard , Daniel J. Hook , Robert B. Steffen , Daniel M. Ammon , Jennifer M. Hunt , Analuz Mark
摘要： An ophthalmic device is disclosed that is a polymerization product of a monomeric mixture comprising: (a) a major amount of one or more non-silicone-containing hydrophilic monomers; (b) a crosslinking agent mixture comprising (i) one or more first crosslinking agents containing at least two ethylenically unsaturated reactive end groups, wherein the at least two ethylenically unsaturated reactive end groups are (meth)acrylate-containing reactive end groups and (ii) one or more second crosslinking agents containing at least two ethylenically unsaturated reactive end groups wherein at least one of the ethylenically unsaturated reactive end groups is a non-(meth)acrylate reactive end group, and (c) one or more hydrophilic polymers or copolymers comprising one or more hydrophilic units and a thio carbonyl thio fragment of a reversible addition fragmentation chain transfer (“RAFT”) agent wherein the ophthalmic device has an equilibrium water content of at least about 45 weight percent.
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