公开(公告)号：US20240124522A1

公开(公告)日：2024-04-18

申请号：US18299600

申请日：2023-04-12

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Donald Bierer ,  Ingo Flamme ,  Dmitry Zubov ,  Thomas Neubauer ,  Adrian Tersteegen ,  Cathleen Juhl ,  Marie Glatz ,  Jan Dreher ,  Simon Holton ,  Carsten Terjung ,  Lars Baumann ,  Thorsten Poethko ,  Jiancheng Xiong ,  Yibo Qiu

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61K45/06 ,  A61P13/12

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K45/06 ,  A61P13/12

摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.

公开(公告)号：US11667675B2

公开(公告)日：2023-06-06

申请号：US17138447

申请日：2020-12-30

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Donald Bierer ,  Ingo Flamme ,  Dmitry Zubov ,  Thomas Neubauer ,  Adrian Tersteegen ,  Cathleen Juhl ,  Marie Glatz ,  Jan Dreher ,  Simon Holton ,  Carsten Terjung ,  Lars Baumann ,  Thorsten Poethko ,  Jiancheng Xiong ,  Yibo Qiu

IPC分类号： C07K7/08 ,  A61P13/12 ,  A61K38/10 ,  A61K45/06

CPC分类号： C07K7/08 ,  A61K38/10 ,  A61K45/06 ,  A61P13/12

摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.