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公开(公告)号:US10722501B2
公开(公告)日:2020-07-28
申请号:US16300480
申请日:2017-05-08
发明人: Nicole Biber , Damian Brockschnieder , Kersten Matthias Gericke , Florian Kölling , Klemens Lustig , Jörg Meding , Heinrich Meier , Thomas Neubauer , Martina Schäfer , Andreas Timmermann , Dmitry Zubov , Carsten Terjung , Niels Lindner , Volker Badock , Dieter Moosmayer , Hideki Miyatake Ondozabal , Stephen Moore , Alexander Schulz
IPC分类号: A61K31/437 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4709 , A61K31/497 , C07D519/00 , A61K45/06 , A61K31/444 , A61P11/00 , A61P29/00
摘要: The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号:US11136296B2
公开(公告)日:2021-10-05
申请号:US16603719
申请日:2018-04-04
发明人: Hartmut Beck , Raimund Kast , Mark Meininghaus , Lisa Dietz , Chantal Fuerstner , Timo Stellfeld , Sonja Anlauf , Clemens-Jeremias Von Buehler , Michaela Bairlein , Johanna Anlahr , Uwe Muenster , Carsten Terjung , Hannah Joerissen , Peter Hauff , Joerg Mueller , Karoline Droebner , Jens Nagel
IPC分类号: C07D215/50
摘要: The present application relates to novel substituted N-arylethyl-2-arylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and inflammatory disorders.
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公开(公告)号:US20240124522A1
公开(公告)日:2024-04-18
申请号:US18299600
申请日:2023-04-12
发明人: Donald Bierer , Ingo Flamme , Dmitry Zubov , Thomas Neubauer , Adrian Tersteegen , Cathleen Juhl , Marie Glatz , Jan Dreher , Simon Holton , Carsten Terjung , Lars Baumann , Thorsten Poethko , Jiancheng Xiong , Yibo Qiu
摘要: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号:US11667675B2
公开(公告)日:2023-06-06
申请号:US17138447
申请日:2020-12-30
发明人: Donald Bierer , Ingo Flamme , Dmitry Zubov , Thomas Neubauer , Adrian Tersteegen , Cathleen Juhl , Marie Glatz , Jan Dreher , Simon Holton , Carsten Terjung , Lars Baumann , Thorsten Poethko , Jiancheng Xiong , Yibo Qiu
摘要: The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号:US11337973B2
公开(公告)日:2022-05-24
申请号:US16761713
申请日:2018-10-31
发明人: Nicole Biber , Damian Brockschnieder , Florian Kölling , Jörg Meding , Hideki Miyatake Ondozabal , Thomas Neubauer , Martina Schäfer , Dmitry Zubov , Carsten Terjung
IPC分类号: A61K31/4985 , C07D487/04 , A61P11/00 , A61K45/06
摘要: The invention relates to prolyl endopeptidase (PREP) inhibitors of formula (I) which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).
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6.
公开(公告)号:US10479765B2
公开(公告)日:2019-11-19
申请号:US16125645
申请日:2018-09-07
发明人: Hartmut Beck , Tobias Thaler , Raimund Kast , Daniel Meibom , Mark Meininghaus , Carsten Terjung , Martina Delbeck , Klemens Lustig , Uwe Muenster , Britta Olenik
IPC分类号: C07D215/52 , C07D215/60 , C07D401/12 , C07D401/04
摘要: The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and/or inflammatory disorders.
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公开(公告)号:US11123439B2
公开(公告)日:2021-09-21
申请号:US15739111
申请日:2016-06-20
发明人: Hans-Georg Lerchen , Anne-Sophie Rebstock , Yolanda Cancho Grande , Leo Marx , Beatrix Stelte-Ludwig , Carsten Terjung , Christoph Mahlert , Simone Greven , Anette Sommer , Sandra Berndt
IPC分类号: A61K47/68 , A61K47/65 , A61K31/4025 , A61K31/4439
摘要: The present invention relates to novel binder-prodrug conjugates (APDCs) where binders are conjugated with inactive precursor compounds of kinesin spindle protein inhibitors, and to antibody-drug conjugates ADCs and to processes for producing these APDCs and ADCs.
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公开(公告)号:US10022453B2
公开(公告)日:2018-07-17
申请号:US15105486
申请日:2014-12-10
发明人: Hans-Georg Lerchen , Sven Wittrock , Nils Griebenow , Beatrix Stelte-Ludwig , Anette Sommer , Sandra Berndt , Christoph Mahlert , Mario Lobell , Carsten Terjung , Simone Greven , Yolanda Cancho Grande
IPC分类号: A61K38/00 , A61K47/48 , C07D403/12 , C07D231/12 , C07D233/64 , C07D403/14 , C07D405/12 , C07D413/12 , C07D207/335 , C07C53/18 , C07D207/337 , C07K5/062 , C07K5/107 , C07K16/28 , C07K16/32 , A61K47/68
摘要: The present application relates to novel antibody drug conjugates (ADCs), to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for the treatment and/or prophylaxis of diseases and to the use of these ADCs for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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9.
公开(公告)号:US10189788B2
公开(公告)日:2019-01-29
申请号:US15509600
申请日:2015-09-07
发明人: Hartmut Beck , Tobias Thaler , Raimund Kast , Daniel Meibom , Mark Meininghaus , Carsten Terjung , Martina Delbeck , Klemens Lustig , Uwe Muenster , Britta Olenik
IPC分类号: C07D215/52 , C07D215/60 , C07D401/12 , C07D401/04
摘要: The present application relates to novel substituted N,2-diarylquinoline-4-carboxamide derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of fibrotic and/or inflammatory disorders.
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公开(公告)号:US11685714B2
公开(公告)日:2023-06-27
申请号:US16087928
申请日:2017-03-21
发明人: Hans-Georg Lerchen , Anne-Sophie Rebstock , Leo Marx , Sarah Anna Liesa Johannes , Beatrix Stelte-Ludwig , Lisa Dietz , Carsten Terjung , Christoph Mahlert , Simone Greven , Anette Sommer , Sandra Berndt
IPC分类号: C07D207/335 , A61K47/65 , A61K47/68 , C07D401/12 , C07D401/14
CPC分类号: C07D207/335 , A61K47/65 , A61K47/6803 , A61K47/6845 , A61K47/6849 , A61K47/6889 , C07D401/12 , C07D401/14
摘要: The invention relates to novel prodrugs or conjugates of the general formula (Ia)
in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.
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