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公开(公告)号：US20240124522A1
公开(公告)日：2024-04-18
申请号：US18299600
申请日：2023-04-12
发明人： Donald Bierer , Ingo Flamme , Dmitry Zubov , Thomas Neubauer , Adrian Tersteegen , Cathleen Juhl , Marie Glatz , Jan Dreher , Simon Holton , Carsten Terjung , Lars Baumann , Thorsten Poethko , Jiancheng Xiong , Yibo Qiu
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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![Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-C][1,2,4]triazol-3-ones, and use thereof](/abs-image/US/2020/07/28/US10722501B2/abs.jpg.150x150.jpg)
公开(公告)号：US10722501B2
公开(公告)日：2020-07-28
申请号：US16300480
申请日：2017-05-08
发明人： Nicole Biber , Damian Brockschnieder , Kersten Matthias Gericke , Florian Kölling , Klemens Lustig , Jörg Meding , Heinrich Meier , Thomas Neubauer , Martina Schäfer , Andreas Timmermann , Dmitry Zubov , Carsten Terjung , Niels Lindner , Volker Badock , Dieter Moosmayer , Hideki Miyatake Ondozabal , Stephen Moore , Alexander Schulz
IPC分类号： A61K31/437 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4709 , A61K31/497 , C07D519/00 , A61K45/06 , A61K31/444 , A61P11/00 , A61P29/00
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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![Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors](/abs-image/US/2022/05/24/US11337973B2/abs.jpg.150x150.jpg)
公开(公告)号：US11337973B2
公开(公告)日：2022-05-24
申请号：US16761713
申请日：2018-10-31
发明人： Nicole Biber , Damian Brockschnieder , Florian Kölling , Jörg Meding , Hideki Miyatake Ondozabal , Thomas Neubauer , Martina Schäfer , Dmitry Zubov , Carsten Terjung
IPC分类号： A61K31/4985 , C07D487/04 , A61P11/00 , A61K45/06
摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors of formula (I) which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).
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公开(公告)号：US11667675B2
公开(公告)日：2023-06-06
申请号：US17138447
申请日：2020-12-30
发明人： Donald Bierer , Ingo Flamme , Dmitry Zubov , Thomas Neubauer , Adrian Tersteegen , Cathleen Juhl , Marie Glatz , Jan Dreher , Simon Holton , Carsten Terjung , Lars Baumann , Thorsten Poethko , Jiancheng Xiong , Yibo Qiu
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号：US20160244415A1
公开(公告)日：2016-08-25
申请号：US15034995
申请日：2014-11-05
发明人： Chantal Furstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Dmitry Zubov , Jens Schamberger
IPC分类号： C07D239/557 , A61K31/513 , C07D413/10 , C07D413/04 , C07D417/04 , A61K9/08 , C07D403/14 , C07D417/14 , C07D413/14 , A61K45/06 , A61K9/00 , A61K9/20 , C07D403/10 , C07D403/04
CPC分类号： C07D239/557 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Substituted uracil derivatives of formula (I), processes for their preparation, their use alone or in combinations for the treatment and/or prophylaxis of diseases, and their use for preparing medicaments for the treatment and/or prophylaxis of diseases.
摘要翻译： 式（I）的取代的尿嘧啶衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途。
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公开(公告)号：US20150148340A1
公开(公告)日：2015-05-28
申请号：US14399945
申请日：2013-05-03
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： C07D417/14 , A61K31/513 , C07D405/14 , A61K45/06 , C07D417/04 , C07D401/04 , C07D409/14 , C07D403/04 , C07D413/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新颖的双环取代的尿嘧啶衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产用于治疗和/或预防 疾病
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公开(公告)号：US09949978B2
公开(公告)日：2018-04-24
申请号：US15288982
申请日：2016-10-07
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/506 , A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/536
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US09949977B2
公开(公告)日：2018-04-24
申请号：US15288968
申请日：2016-10-07
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/506 , A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/536
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US10300062B2
公开(公告)日：2019-05-28
申请号：US15912185
申请日：2018-03-05
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer , Kirsten Börngen
IPC分类号： A61K31/513 , C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K45/06 , C07D405/14 , C07D417/14 , A61K31/538 , A61K31/506 , A61K31/536
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases.
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公开(公告)号：US09751843B2
公开(公告)日：2017-09-05
申请号：US15034499
申请日：2014-11-05
发明人： Chantal Fürstner , Jens Ackerstaff , Alexander Straub , Heinrich Meier , Hanna Tinel , Katja Zimmermann , Adrian Tersteegen , Dmitry Zubov , Raimund Kast , Jens Schamberger , Martina Schäfer
IPC分类号： C07D239/557 , C07D413/14 , C07D403/10 , C07D413/10 , A61K31/513 , C07D409/06 , C07D417/10
CPC分类号： C07D239/557 , A61K31/513 , C07D403/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/10
摘要： Substituted uracil derivatives of the compound of Formula (I), processes for their preparation, their use alone or in combinations for treatment and/or prophylaxis of diseases, and their use for preparing medicaments for treatment and/or prophylaxis of diseases.
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