公开(公告)号：US11154064B2

公开(公告)日：2021-10-26

申请号：US15511839

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: C07K14/325 ,  A01N63/00 ,  A01N25/00 ,  A61K38/00 ,  A01N63/50 ,  C12N15/63 ,  C12N15/82 ,  C12N15/866 ,  C12N15/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US11406107B2

公开(公告)日：2022-08-09

申请号：US16935020

申请日：2020-07-21

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/50 ,  C07K14/325 ,  C12N15/63 ,  C12N15/82 ,  C12N15/866 ,  A01N25/00 ,  A61K38/00 ,  C12N15/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one further biological control agent selected from particular microorganisms disclosed herein and/or a mutant of a specific strain of a microorganism disclosed herein having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20170290339A1

公开(公告)日：2017-10-12

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian THOMPSON

IPC: A01N63/00 ,  A01N43/90 ,  A01N47/22 ,  A01N43/22

CPC classification number: A01N63/00 ,  A01N43/22 ,  A01N43/90 ,  A01N47/22 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  Y02A50/356 ,  A01N43/56 ,  A01N47/40 ,  A01N53/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20240316173A1

公开(公告)日：2024-09-26

申请号：US18654255

申请日：2024-05-03

Applicant: Spogen Biotech Inc. ,  Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  A61K2035/115

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20240285745A1

公开(公告)日：2024-08-29

申请号：US18654243

申请日：2024-05-03

Applicant: Spogen Biotech Inc. ,  Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  A61K2035/115

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular fungicide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20240285743A1

公开(公告)日：2024-08-29

申请号：US18644663

申请日：2024-04-24

Applicant: Spogen Biotech Inc. ,  Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  A61K2035/115 ,  Y02A50/30

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US12016912B2

公开(公告)日：2024-06-25

申请号：US17356958

申请日：2021-06-24

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  A61K2035/115 ,  Y02A50/30 ,  A01N63/50 ,  A01N63/22 ,  A01N63/50 ,  A01N43/22 ,  A01N43/56 ,  A01N43/90 ,  A01N47/22 ,  A01N47/40 ,  A01N53/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US20240285744A1

公开(公告)日：2024-08-29

申请号：US18644678

申请日：2024-04-24

Applicant: Spogen Biotech Inc. ,  Bayer CropScience LP

Inventor： Damian Curtis ,  Brian Thompson

IPC: A61K39/07 ,  A61K35/00 ,  A61K35/742

CPC classification number: A61K39/07 ,  A61K35/742 ,  C12Y301/01 ,  C12Y302/01004 ,  C12Y302/01132 ,  A61K2035/115 ,  Y02A50/30

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US11044916B2

公开(公告)日：2021-06-29

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.

公开(公告)号：US10897909B2

公开(公告)日：2021-01-26

申请号：US15511864

申请日：2015-09-17

Applicant: Bayer CropScience LP ,  Spogen Biotech Inc.

Inventor： Damian Curtis ,  Brian Thompson

IPC: A01N63/00

Abstract: The present invention relates to a composition comprising a) recombinant exosporium-producing Bacillus cells that express a fusion protein comprising: (i) at least one plant growth stimulating protein or peptide and (ii) a targeting sequence that localizes the fusion protein to the exosporium of the Bacillus cells; and b) at least one particular insecticide disclosed herein in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for enhancing plant growth, promoting plant health, and/or reducing overall damage of plants and plant parts.