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    Slope-Based Compensation Including Secondary Output Signals
    2.
    发明申请
    Slope-Based Compensation Including Secondary Output Signals 有权
    包括次级输出信号的斜率补偿

    公开(公告)号：US20150377819A1

    公开(公告)日：2015-12-31

    申请号：US14846174

    申请日：2015-09-04

    Applicant: BAYER HEALTHCARE LLC

    Inventor： Dijia Huang ,  Huan-Ping Wu

    IPC: G01N27/327

    CPC classification number: G01N27/3274 ,  G01N33/48714

    Abstract: A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.

    Abstract translation: 生物传感器系统从分析和/或次要输出信号确定分析物浓度。 生物传感器系统通过从输出信号提取的一个或多个指数函数来调整从输出信号确定分析物浓度的相关性。 索引函数确定与一个或多个错误参数的至少一个斜率偏差或归一化斜率偏差。 可以使用分析物浓度和输出信号之间的斜率调整的相关性来确定包括归因于偏压的成分的输出信号具有改进的精度和/或精度的分析物浓度。

    Method For Manufacturing A Lot Of Test Sensors
    5.
    发明申请
    Method For Manufacturing A Lot Of Test Sensors 审中-公开
    制造大量测试传感器的方法

    公开(公告)号：US20150260677A1

    公开(公告)日：2015-09-17

    申请号：US14727315

    申请日：2015-06-01

    Applicant: Bayer HealthCare LLC

    Inventor： Sung-Kwon Jung ,  Dijia Huang ,  Steven C. Charlton

    IPC: G01N27/327

    CPC classification number: C25D11/02 ,  C12Q1/001 ,  G01N27/3272 ,  Y10T29/49117

    Abstract: Systems and methods for electrochemically oxidizing components of a test-sensor reagent prior to deposition on a test sensor comprise at least a first electrode and a second electrode for contacting the test-sensor reagent. The first electrode and the second electrode may have hollow interior portions for contacting the test-sensor reagent to produce a modified test-sensor reagent having a reduced background current.

    Abstract translation: 在测试传感器上沉积之前对测试传感器试剂的组分进行电化学氧化的系统和方法包括用于接触测试传感器试剂的至少第一电极和第二电极。 第一电极和第二电极可以具有用于接触测试传感器试剂以产生具有降低的背景电流的修改的测试传感器试剂的中空内部部分。

    Determining Analyte Concentration From Variant Concentration Distribution In Measurable Species
    7.
    发明申请
    Determining Analyte Concentration From Variant Concentration Distribution In Measurable Species 审中-公开
    从可变物种中的变异浓度分布确定分析物浓度

    公开(公告)号：US20150176054A1

    公开(公告)日：2015-06-25

    申请号：US14643134

    申请日：2015-03-10

    Applicant: Bayer HealthCare LLC

    Inventor： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    IPC: C12Q1/54

    CPC classification number: C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

    Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

    Abstract translation: 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

    Transient decay amperometry biosensors
    8.
    发明授权
    Transient decay amperometry biosensors 有权
    瞬态衰变电流分析生物传感器

    公开(公告)号：US09005527B2

    公开(公告)日：2015-04-14

    申请号：US13904208

    申请日：2013-05-29

    Applicant: Bayer Healthcare LLC

    Inventor： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

    IPC: G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  C12Q1/00 ,  G01N27/00 ,  A61B5/1455 ,  A61B5/1495

    CPC classification number: C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

    Abstract: A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

    Abstract translation: 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

    Electrochemical-sensor design
    9.
    再颁专利
    Electrochemical-sensor design 有权
    电化学传感器设计

    公开(公告)号：USRE45384E1

    公开(公告)日：2015-02-24

    申请号：US14022189

    申请日：2013-09-09

    Applicant: Bayer HealthCare LLC

    Inventor： Matthew K. Musho ,  J. Oakey Noell ,  Andrew J. Edelbrock ,  Dijia Huang

    IPC: G01N27/327

    CPC classification number: C12Q1/001 ,  G01N27/3274

    Abstract: An electrochemical test sensor adapted to assist in determining the concentration of analyte in a fluid sample is disclosed. The sensor comprises a base that assists in forming an opening for introducing the fluid sample, a working electrode being coupled to the base, and a counter electrode being coupled to the base, the counter electrode and the working electrode being adapted to be in electrical communication with a detector of electrical current, and a sub-element being coupled to the base. A major portion of the counter electrode is located downstream relative to the opening and at least a portion of the working electrode. The sub-element is located upstream relative to the working electrode such that when electrical communication occurs between only the sub-element and the working electrode there is insufficient flow of electrical current through the detector to determine the concentration of the analyte in the fluid sample.

    Abstract translation: 公开了一种适用于帮助确定流体样品中分析物浓度的电化学测试传感器。 传感器包括有助于形成用于引入流体样品的开口的基座，耦合到基座的工作电极和耦合到基座的对电极，对电极和工作电极适于电连通 具有电流检测器，以及耦合到基座的子元件。 对电极的主要部分位于开口和工作电极的至少一部分的下游。 子元件相对于工作电极位于上游，使得当仅在子元件和工作电极之间发生电连通时，通过检测器的电流不足以确定流体样品中分析物的浓度。

    Electrochemical Biosensor
    10.
    发明申请
    Electrochemical Biosensor 有权
    电化学生物传感器

    公开(公告)号：US20140202881A1

    公开(公告)日：2014-07-24

    申请号：US14224899

    申请日：2014-03-25

    Applicant: Bayer HealthCare LLC

    Inventor： Dijia Huang ,  Steven C. Charlton ,  Suny J. George ,  Andrew J. Edelbrock

    IPC: G01N27/327

    CPC classification number: G01N27/3272 ,  C12Q1/006 ,  G01N27/3274 ,  G01N27/3275 ,  G01N27/4163 ,  Y10T29/49082 ,  Y10T29/49099

    Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.

    Abstract translation: 根据本发明的一个实施例，公开了一种用于检测流体测试样品中分析物浓度的电化学传感器（10）。 传感器（10）包括具有高电阻部分的对电极，用于检测测试传感器是否已接收到预定量的样本。

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