公开(公告)号：US20040161854A1

公开(公告)日：2004-08-19

申请号：US10776063

申请日：2004-02-11

Applicant: Bayer HealthCare LLC ,  Worcester Polytechnic Institute

Inventor： John S. Benco ,  Hubert A. Nienaber ,  W. Grant McGimpsey

IPC: G01N021/64

CPC classification number: C07D498/08 ,  G01N21/6428 ,  G01N31/22 ,  G01N33/84 ,  G01N2021/7786

Abstract: The present invention relates to a novel device and method for the detection of lithium ions in a biological fluid. In a preferred embodiment, the present invention provides a novel compound and a optical sensor which incorporates said compound for the detection of lithium ions. Additionally, the present invention provides a method of detecting lithium ions which comprises placing the novel optical sensor into communication with a biological fluid. Once the novel compound of the present invention encounters a lithium ion(s), a fluorescence is generated, the intensity of which is measured and allows for the determination of lithium ion concentration. The present invention provides a medical professional with the ability to selectively determine lithium ion concentration in a biological fluid thereby facilitating the treatment of various diseases, such as manic-depressive illness.

Abstract translation: 本发明涉及用于检测生物液体中的锂离子的新型装置和方法。 在优选的实施方案中，本发明提供了一种新型化合物和光学传感器，其结合了用于检测锂离子的所述化合物。 此外，本发明提供一种检测锂离子的方法，其包括将新型光学传感器与生物流体连通。 一旦本发明的新化合物遇到锂离子，就产生​​荧光，其强度被测量并允许测定锂离子浓度。 本发明提供一种具有选择性地测定生物体液中的锂离子浓度的能力的医疗专业人员，从而便于治疗各种疾病，例如躁狂抑郁症。