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公开(公告)号：US20210053941A1
公开(公告)日：2021-02-25
申请号：US17009553
申请日：2020-09-01
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20220388982A1
公开(公告)日：2022-12-08
申请号：US17869674
申请日：2022-07-20
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20190388410A1
公开(公告)日：2019-12-26
申请号：US16428669
申请日：2019-05-31
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K45/06 , A61P35/00 , A61K31/519
摘要： The present application relates to novel combinations of at least two components, component A and component B: component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：US20220241261A1
公开(公告)日：2022-08-04
申请号：US17544641
申请日：2021-12-07
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K31/519 , A61K31/497 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/55 , A61K31/506 , A61K31/454 , A61K31/505 , A61P35/00 , A61K45/06
摘要： The present application relates to novel combinations of at least two components, component A and component B: component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：US20170349570A1
公开(公告)日：2017-12-07
申请号：US15529996
申请日：2015-11-25
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , C07D405/14
CPC分类号： C07D401/12 , C07D405/14 , C07F7/1804
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20230174508A1
公开(公告)日：2023-06-08
申请号：US17869673
申请日：2022-07-20
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
CPC分类号： C07D401/12 , C07F7/1804 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20190233395A1
公开(公告)日：2019-08-01
申请号：US16377025
申请日：2019-04-05
发明人： Ulrich BOTHE , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Alexandra RAUSCH , Christian FRIEDRICH , Peter HAUFF
IPC分类号： C07D401/12 , C07F7/18 , A61P19/02 , A61K31/4439 , C07D405/14
摘要： The present application relates to novel substituted indazoles, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis and endometriosis-associated pain and other endometriosis-associated symptoms such as dysmenorrhoea, dyspareunia, dysuria and dyschezia, of lymphoma, rheumatoid arthritis, spondyloarthritis (especially psoriatic spondyloarthritis and Bekhterev's disease), lupus erythematosus, multiple sclerosis, macular degeneration, COPD, gout, fatty liver disorders, insulin resistance, neoplastic disorders and psoriasis.
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公开(公告)号：US20180289685A1
公开(公告)日：2018-10-11
申请号：US15570212
申请日：2016-04-29
发明人： Ulrich BOTHE , Antje Margret WENGNER , Holger SIEBENEICHER , Nicole SCHMIDT , Reinhard NUBBEMEYER , Ulf BÖMER , Judith GÜNTHER , Holger STEUBER , Martin LANGE , Christian STEGMANN , Andreas SUTTER , Roland NEUHAUS
IPC分类号： A61K31/4439 , A61K31/519 , A61K45/06 , A61P35/00
摘要： The present application relates to novel combinations of at least two components, component A and component B: ⋅component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; ⋅component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, ⋅one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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