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公开(公告)号：US20220274979A1
公开(公告)日：2022-09-01
申请号：US17048561
申请日：2019-04-15
发明人： Lars WORTMANN , Brice SAUTIER , Knut EIS , Hans BRIEM , Niels BÖHNKE , Franz VON NUSSBAUM , Roman HILIG , Benjamin BADER , Jens SCHRÖDER , Kirstin PETERSEN , Philip LIENAU , Antje Margret WENGNER , Dieter MOOSMAYER , Qiuwen WANG , Hans SCHICK
IPC分类号： C07D471/04 , C07D487/04
摘要： The present invention covers 2-methyl-aza-quinazoline compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients
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公开(公告)号：US20170202815A1
公开(公告)日：2017-07-20
申请号：US15477974
申请日：2017-04-03
发明人： Ulrich LÜCKING , Niels BÖHNKE , Arne SCHOLZ , Philip LIENAU , Gerhard SIEMEISTER , Ulf BÖMER , Dirk KOSEMUND , Rolf BOHLMANN , Ludwig ZORN
IPC分类号： A61K31/444
CPC分类号： A61K31/444 , C07D213/72 , C07D401/12
摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).
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