公开(公告)号：US10047096B2

公开(公告)日：2018-08-14

申请号：US15529043

申请日：2015-11-23

申请人： Bayer Pharma Aktiengesellschaft ,  Petra Heinrich-Keldenich

发明人： Andreas Schall ,  Jürgen Klar ,  Mario Lobell ,  Hartmut Schirok ,  Joachim Telser ,  Steffen Müller ,  Dirk Brohm ,  Hans Briem ,  Hannah Jörißen ,  Joerg Keldenich ,  Michael Böttger ,  Georges Von Degenfeld ,  Thomas Schlange ,  Ulf Bömer ,  Niels Lindner ,  Hanna Eilken ,  Dmitrij Hristodorov ,  Pierre Wasnaire ,  Kersten Matthias Gericke ,  Lars Bärfacker

IPC分类号： A61K31/551 ,  C07D471/04 ,  C07D487/04 ,  A61K31/5513 ,  A61K39/395

摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.

公开(公告)号：US20150165028A1

公开(公告)日：2015-06-18

申请号：US14407527

申请日：2013-06-10

申请人： Petra Heinrich-Keldenich ,  Bayer Healthcare LLC

发明人： Michael Bottger ,  Georges Von Degenfeld ,  Julia Freundlieb ,  Claudia Hirth-Dietrich ,  Joerg Keldenich ,  Jurgen Klar ,  Uwe Muenster ,  Andreas Ohm ,  Annett Richter ,  Bernd Riedl ,  Joachim Telser

IPC分类号： A61K47/06 ,  A61K9/00 ,  A61K31/517

CPC分类号： A61K47/06 ,  A61K9/0048 ,  A61K9/10 ,  A61K31/517

摘要： The present invention relates to topical ophthalmological pharmaceutical compositions containing cediranib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.

摘要翻译： 本发明涉及含有西地那非，其水合物，溶剂合物或其药学上可接受的盐或其多晶型物的局部眼科药物组合物及其制备方法及其用于治疗眼科疾病的用途。