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公开(公告)号：US10047096B2
公开(公告)日：2018-08-14
申请号：US15529043
申请日：2015-11-23
发明人： Andreas Schall , Jürgen Klar , Mario Lobell , Hartmut Schirok , Joachim Telser , Steffen Müller , Dirk Brohm , Hans Briem , Hannah Jörißen , Joerg Keldenich , Michael Böttger , Georges Von Degenfeld , Thomas Schlange , Ulf Bömer , Niels Lindner , Hanna Eilken , Dmitrij Hristodorov , Pierre Wasnaire , Kersten Matthias Gericke , Lars Bärfacker
IPC分类号： A61K31/551 , C07D471/04 , C07D487/04 , A61K31/5513 , A61K39/395
摘要： The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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2.发明申请TOPICAL OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION CONTAINING CEDIRANIB 审中-公开含有CEDIRANIB的局部OPHTHALMOLOGICAL PHARMACEUTICAL COMPOSITION公开(公告)号：US20150165028A1
公开(公告)日：2015-06-18
申请号：US14407527
申请日：2013-06-10
发明人： Michael Bottger , Georges Von Degenfeld , Julia Freundlieb , Claudia Hirth-Dietrich , Joerg Keldenich , Jurgen Klar , Uwe Muenster , Andreas Ohm , Annett Richter , Bernd Riedl , Joachim Telser
IPC分类号： A61K47/06 , A61K9/00 , A61K31/517
CPC分类号： A61K47/06 , A61K9/0048 , A61K9/10 , A61K31/517
摘要： The present invention relates to topical ophthalmological pharmaceutical compositions containing cediranib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
摘要翻译： 本发明涉及含有西地那非，其水合物，溶剂合物或其药学上可接受的盐或其多晶型物的局部眼科药物组合物及其制备方法及其用于治疗眼科疾病的用途。
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公开(公告)号：US09688636B2
公开(公告)日：2017-06-27
申请号：US14609122
申请日：2015-01-29
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/48 , A61K31/4706 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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公开(公告)号：US09624199B2
公开(公告)日：2017-04-18
申请号：US15106286
申请日：2014-12-16
发明人： Eva Maria Becker-Pelster , Philipp Buchgraber , Anja Buchmüller , Karen Engel , Andreas Göller , Herbert Himmel , Raimund Kast , Joerg Keldenich , Carsten Schmeck , Hanna Tinel , Frank Wunder
IPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/541 , A61K45/06 , A61K31/5377 , C07D491/107
CPC分类号： C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/06 , C07D403/14 , C07D413/14 , C07D491/107
摘要： The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
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公开(公告)号：US20150148376A1
公开(公告)日：2015-05-28
申请号：US14609122
申请日：2015-01-29
发明人： Michael HAHN , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , IIdiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/48 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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公开(公告)号：US08981104B2
公开(公告)日：2015-03-17
申请号：US13945675
申请日：2013-07-18
发明人： Michael Hahn , Markus Follmann , Walter Hübsch , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin
IPC分类号： C07D215/38 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4706 , A61K31/4709 , A61K45/06
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
摘要翻译： 本申请涉及新的5-氨基-5,6,7,8-四氢喹啉-2-羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管和心肺疾病的药物。
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公开(公告)号：US10053428B2
公开(公告)日：2018-08-21
申请号：US15600132
申请日：2017-05-19
发明人： Michael Hahn , Markus Follmann , Eva-Maria Becker , Johannes-Peter Stasch , Joerg Keldenich , Martina Delbeck , Hanna Tinel , Frank Wunder , Joachim Mittendorf , Ildiko Terebesi , Dieter Lang , René Martin , Walter Hübsch
IPC分类号： A61K31/4706 , C07D215/48 , C07D217/26 , C07D401/12 , C07D413/12 , A61K31/4709 , A61K45/06 , A61K31/47
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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